SBM: Pharmacology & therapeutics - NSAIDs Flashcards
Which of these are NSAIDs: Tramadol, Naproxen, Indomethacin, Aspirin, Celecoxib.
Naproxen, Indomethacin, Celecoxib
What can NSAIDs be used for?
Analgesia and anti inflammatory
As an analgesic what can NSAIDs be used for?
Headache, back pain, dysmenorrhoea, dental pain, peri/post op pain
What can NSAIDs be used for in Antiinflammatory conditions?
Gout, Rheumatoid arthritis, SLE. CAN TAKE UP TO THREE WEEKS FOR EFFECT
Describe the mechanism of action of NSAIDs.
blocks COX. Therefore stops Prostaglandins. This stops Inflammation and pain. (PGI2). It also inhibits: Protect Gastric mucosa, supportive renal functions, and supportive platelet functions.
NSAIDs blocks what?
COX.
Talk about the 2 COX pathways
COX 1 - inhibition is undesirable. As this is responsible for Stomach, intestine, Kidney support. As well as platelet Thromboxane A2 support. COX 2 - Inhibtion is wanted. This reduced inflammation (macrophages).
Apart from NSAIDs. What selectively blocks COX 2?
Glucocorticoid
NSAIDs have selectively COX 2 inhibitors. Name a few
Etoricoxib, celecoxib
-coxibs
how effect are -coxibs compared to diclofenac?
As effective
What are the benefits/cons of Coxibs
Pro: Reduced Upper GI events. Cons: increased Thrombotic risk.
What is the evidence of thrombotic risk in traditional NSAIDs?
Diclofenac - increase risk. Naproxen - lower than other NSAIDs. Ibuprofen - no increase/little risk
Name a few side effects of NSAIDs?
GI discomfort. peptic ulcers, Renal: fluid retention.Hypertension.
What important drug interaction should be noted?
Anticoagulants, Antihypertensives, Corticosteroids, SSRIs
