SBM: Pharmacology & therapeutics - Coagulation

Question 1

What are the 3 causes of bleeding?

Answer 1

Vascular disorders, platelet disorders, and defective coagulation

Question 2

What does thrombocytopenia mean?

Answer 2

Low platelets <150

Question 3

when can symptoms for thrombocytopenia arise?

Answer 3

Under 10

Question 4

What does ITP stand for?

Answer 4

Immune Thrombocytopena

Question 5

How do you treat ITP?

Answer 5

steroids/IV immunoglobulins/ Splenectomy

Question 6

Name a coagulation disorder

Answer 6

Haemophilia

Question 7

Describe the coagulation cascade

Answer 7

> 100

Question 8

What is the difference between haemophilia A and B?

Answer 8

A = deficiency of Factor VIII (8)
B = deficiency of factor IX (9)

Question 9

What is Christmas Disease

Answer 9

Haemophilia B

Question 10

Does haemophilia affect males or females? And WHy?

Answer 10

Males

Because they are X Linked conditions

Question 11

What are the features of haemophilia

Answer 11

Spontaneous bleeding into joints and muscle. Post Op bleeding.

Question 12

How can you test coagulation?

Answer 12

APTT = Activated Partial thromboplastin time. PT = Prothrombin Time. TT= thrombin time.
FIBRINOGEN level.

Question 13

What does APTT test?

Answer 13

Intrinisic pathway

Question 14

What does PT test?

Answer 14

Extrinsic Pathway

Question 15

Desrcribe the findings with someone with a diagnosis of haemophilia.

Answer 15

Prolonged APTT, Normal PT, Low Factor 8/9