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pharma > SAS#19 > Flashcards

SAS#19 Flashcards

1
Q

Lower serum levels of cholesterol and various lipids. They are also called as lipid-lowering agents

A

ANTIHYPERLIPIDEMIC DRUGS

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2
Q

C a d is the leading cause of death worldwide and its incidence is highly and people with

A

HYPERLIPIDEMIA

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3
Q

These drugs are used to normalize high serum levels of cholesterol

A

BILE ACID SEQUESTRANTS

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4
Q

Exert their effect in the intestine by binding into bile acids which contain a high level of cholesterol

A

BILE ACID SEQUESTRANTS

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5
Q

Is also used to treat pruritus associated with partial biliary obstruction

A

CHOLESTYRAMINE

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6
Q

this drug group increases the cell absorption of ldl by blocking the enzyme regulating the rate-limiting step in the synthesis of cholesterol

A

HMG CoA REDUCTASE INHIBITORS

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7
Q

Block the completion of cholesterol synthesis in the body

A

HMG Coa reductase inhibitors

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8
Q

Are indicated for patients with documented c a d to slow progression of the disease

A

PRAVASTATIN
LOVASTATIN
SIMVASTATIN

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9
Q

Pravastatin lovastatin and simvastatin, together with this three agents _____ is used as prophylaxis for first myocardial infarction attack for patients with multiple risk factors for c a d

A

ATORVASTATIN

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10
Q

Is the drug of choice for patients who have multiple risk factor or have already develop c a d

A

HMG-COA REDUCTASE INHIBITOR

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11
Q

This class is well tolerated and is less expensive compared to other classes with the same therapeutic effect

A

HMG-

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12
Q

Increased serum levels and resultant of hmg-coa reductase inhibitors

A

DIGOXIN
WARFARIN

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13
Q

Atorvastatin can be given at

A

ANY HOUR OF THE DAY

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14
Q

administered drug at bedtime to maximize effectiveness of the drugs because pic of cholesterol synthesis is from midnight to 5:00 a.m.

A

HMG COA REDUCTASE INHIBITOR

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15
Q

Are one of the new class of drug approved to lower serum cholesterol levels

A

CHOLESTEROL ABSORPTION INHIBITOR

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16
Q

Acting on the brush border of intestine,_____block the absorption of dietary cholesterol

A

CHOLESTEROL ABSORPTION INHIBITOR

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17
Q

Increased toxicity of cholesterol absorption inhibitors

A

CYCLOSPORINE

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18
Q

Increased risk for development of cholelithiasis

A

FIBRATES

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19
Q

Altering the formation of platelet plug

A

ANTIPLATELET DRUG

20
Q

Altering interfering the clotting cascade and thrombin formation

A

ANTICOAGULANT DRUGS

21
Q

Altering the stimulating of the plasmin system to break down the formed class

A

THROMBOLYTIC AGENTS

22
Q

DisOrders that directly affect coagulation process

A

THROMBOEMBOLIC DISORDERS
HEMORRHAGIC DISORDERS

23
Q

Which involve overproduction of clots

A

THROMBOEMBOLIC DISORDERS

24
Q

Which is characterized by ineffective clotting process leading to excessive bleeding

A

HEMORRHAGIC DISORDERS

25
Q

Include medical conditions which involve overproduction of clots which result in to decrease blood flow and total vessel occlusion

A

THROMBOEMBOLIC DISORDERS

26
Q

Conditions under hemorrhagic disorders

A

HEMOPHILIA
LIVER DISEASE
BONE MARROW DISORDERS

27
Q

Characterized by genetic lack of clotting factors

A

HEMOPHILIA

28
Q

Characterized by non production of proteins and clotting factors necessary for clot formation

A

LIVER DISEASE

29
Q

Characterized by in sufficient quantity of platelets rendering them ineffective

A

BONE MARROW DISORDERS

30
Q

THROMBOEMBOLIC disorders manifestations include

A

Hypoxia
Anoxia
Necrosis

31
Q

This drug class exerts action by decreasing the responsiveness of platelets to stimuli that cause it to clump or aggregate

A

ANTIPLATELET AGENTS

32
Q

Blocks the production of platelets in the bone marrow

A

ANAGRELIDE

33
Q

Increase risk of bleeding if combined with another drug that affects blood clotting

A

ANTIPLATELET ANGENTS

34
Q

By interfering with clotting cascade and thrombin formation_____are able to interfere with the normal clotting process

A

ANTICOAGULANT

35
Q

Two new oral agents, directly inhibits thrombin and factor xa respectively

A

DABIGATRAN
RIVAROXABAN

36
Q

Is used for prevention of blood clots in blood samples dialysis and venus tubing.
It also does not enter breast milk so it is the anticoagulant of choice for lactating women

A

HEPARIN

37
Q

Block formation of thrombin from prothrombin

A

HEPARIN AND ANTITHROMBIN

38
Q

Antidote of heparin

A

PROTAMINE SULFATE

39
Q

Antidote of warfarin

A

VITAMIN K

40
Q

Blood test for warfarin

A

PROTHROMBIN TIME (PT)
INTERNATIONAL NORMALIZED RATIO(INR)

41
Q

Blood test for heparin

A

WHITE BLOOD CLOTTING TIME
ACTIVATED PARTIAL THROMBOPLASTIN TIME

42
Q

Promote clot resolution,the process of activating the plasmin system to break down the thrombus or clot that has been form

A

THROMBOLYTIC AGENTS

43
Q

Increased risk of bleeding when interaction with thrombolytic agents

A

ANTICOAGULANT AND ANTIPLATELET

44
Q

Evaluate the ability to clot

A

PT

45
Q

Blood thinning effect

A

PTT (60-70 SEC)

46
Q

How many seconds in APTT

A

30-40

pharma (12 decks)

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