Sarcoidosis Flashcards

1
Q

What is Sarcoidosis?

A

Formation of Inflammatory Nodules (Granulomas) across organs e.g. Lungs.

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2
Q

Distinguishing signs of Sarcoidosis?

A

Lofgren’s Syndrome

1) Erythema Nodosum (red, tender shins)
2) Hilar lymphadenopathy
3) Polyarthralgia - painful joints

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3
Q

Other organ signs?

A

Liver: cirrhosis + cholestasis
Heart: bundle branch block, heart block
Eyes: Uveitis, optic neuritis + conjunctivitis

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4
Q

Investigating suspected Sarcoidosis?

A

1) Bedside: ACE, IL2, CRP all raised
2) CXR + High Res CT: Pulmonary nodules + Hilar lymphadenopathy
3) PET scan: active inflammation

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5
Q

Gold Standard Diagnostic Test + signs?

A

Histology/Biopsy: No-caseating Granulomas visible

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6
Q

Management of Mild Sarcoidosis?

A

None

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7
Q

Management of Severe Sarcoidosis?

A

1st line: Bisphosphonates + oral steroids 6-24 months
2nd line: Methotrexate OR azathioprine
Lung Transplant if needed

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8
Q

Most common site of pulmonary fibrosis

A

Upper Lung Zones

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