Sarcoidosis

Question 1

What is sarcoidosis

Answer 1

o Autoimmune inflammatory disease that causes pathologic graulomas to form in two or more organs.
o Other granuloma causes must be ruled out including; fungal infections, malignancy, and environmental exposures to beryllium
o Most common organ affected is the lungs
o Typically young adult to adult females

Question 2

What are s/s of sarcoidosis

Answer 2

o Can be asymptomatic
o Fever, malaise, dyspnea, pain, cough

Question 3

What are diagnostics of sarcoidosis

Answer 3

o CXR
o Bronchial lavage/biopsy is needed to make diagnosis
o Additional Tests
 6-12 month PFTs and CXRs
 EKGS annually
 Annual eye exam
 Stress test to determine risk for sudden cardiac death

Question 4

Sarcoidosis treatment

Answer 4

o NSAIDS
o Steroids
o Methyltrexate
o Hydrochloriquine
o Infliximab or thalidone can be used if refractory
o Cyclosporine if other treatments fail

Question 5

Sarcoidosis staging

Answer 5

o I: bilateral hilar lymphadenopathy
o II: Bilateral hilar lymphadenopathy and infiltrates
o III: Bilateral Infiltrates
o IV : fibrosis