SAM II Exam I Material - Gastrointestinal Flashcards
This is a specific antidote used in Tylenol toxicity
N-acetyl cysteine
N-acetyl cysteine treats acetaminophen (Tylenol) poisoning by binding the poisonous forms of acetaminophen that are formed in the liver
Considering the risks and diagnostic value of each biopsy technique, which biopsy method is the best option for dogs with non-infiltrative/neoplastic liver disease?
- FNA
- Menghini tru-cut
- Laparotomy/laparoscopy
Laparotomy/laparoscopy
T/F: If you note microcytic, hypochromic anemia in a yorkshire terrier, this can be an indicator of poor iron metabolism associated with portosystemic shunts
True
What is the drug of choice for treatment of histiocytic ulcerative colitis?
enrofloxacin
Since histiocytic ulcerative colitis is a bacterial infection, it is antibiotic responsive. Enrofloxacin is typically effective. It is critical to treat for at least 8 weeks (even if the patient feels normal by week 2). Stopping antibiotics before 8 weeks has been associated with recurrence of infection and resistance to enrofloxacin.
Lady, a 6-year-old Labrador has been under your care for CH for 2 months. Today she presents like this. What do you recommend as the first line of treatment?
- Drain all the fluid by abdominocentesis
- Spironolactone at 2 mg/kg/day
- Furosemide at 2 mg/kg/day
- Colloid like hetastarch
Spironolactone at 2 mg/kg/day
T/F: ALT and AST are very liver-specific
False
- ALT is very liver specific*
- AST is also from skeletal muscle and cardiac muscle*
T/F: Both cats and dogs with acute pancreatitis will regularly demonstrate abdominal pain
False
T/F: The current combination of tests with the best test accuracy for the diagnosis of acute pancreatitis is cPL and abdominal ultrasound
True
What is the specific treatment for aflatoxicosis?
Plasma & Vitamin K
T/F: Xylitol toxicosis is associated with hyperglycemia
False
Xylitol stimulates insulin release and results in hypoglycemia
What is the role of H2 blockers and proton pump inhibitors in the medical treatment of esophagitis?
neutralize acid secretion
T/F: Concurrent IBD, cholangiohepatitis and pancreatitis are common in cats
True
These concurrent diseases are referred to collectively as triaditis
What liver disease is associated with the highest mortality rate in cats?
hepatic lipidosis
Lipid accumulation in hepatocytes eventually results in loss of hepatic function.
- Increased triglyceride deposition associated with starvation due to mobilization of fatty acids from lipid stores
- Insufficient insulin – fat stores used for energy
Is the following clinical sign more associated with small bowel diarrhea or large bowel diarrhea:
weight loss and protein loss
small bowel (often in chronic)
What is the mechanism of action of lactulose in resolving hepatic encephalopathy?
- Laxative
- Purgative
- Resolves dysbiosis
- Ion trapping
- Resolves alkalosis
Ion trapping
lactulose acidifies the GIT and traps ammonia; decreases absorption of harmful substances by increasing GIT transit
Current evidence based medicine supports the diagnosis of specific therapy for acute pancreatitis. Which therapy in dogs is not specifically indicated?
- Crystalloid resuscitation
- Fentanyl CRI
- Broad spectrum antibiotics
- Maropitant, NK1 receptor antagonist
Broad-spectrum antibiotics
Which of these is/are classic feature(s) of small bowel enteritis in contrast to large bowel enteritis?
- mucous
- tenesmus
- dyschezia
- hematochezia
- low volume
- hypocobalaminemia
hypocobalaminemia
hypocobalaminemia is more characteristic for small intestinal enteritis
T/F: Both cats and dogs will have obvious ultrasonography changes in acute pancreatitis in >70% of cases
False
Cats are more prone to chronic pancreatitis than acute pancreatitis and it’s difficult to diagnose chronic pancreatitis on ultrasound
T/F: Steroids are indicated for treatment of hepatic lipidosis in cats
False!
T/F: Both cats and dogs will frequently have cholangitis and enteritis accompanying pancreatitis
False
T/F: When using maropitant as an anti-emetic in acute liver disease, it is standard to decrease the recommended dose by ~25%
True
Maropitant is metabolized in the liver, so we generally decrease the dose by ~25% in our acute liver disease patients
Which of these is not a good treatment for IBD in these cats?
- Budesonide
- Prednisolone
- Metronidazole
- Chlorambucil
- Azathioprine
Azathioprine
The most common form of pancreatitis in cats is:
chronic pancreatitis
When submitting a liver biopsy, what special stain would you request if you want to confirm cirrhosis and fibrosis?
Masson’s trichome
T/F: Hepatic encephalopathy (HE) can occur in acute or chronic liver disease as well as portosystemic shunts
True
Corneal edema is a hallmark feature of:
infectious canine hepatitis
A Cairn Terrier is admitted to the ICU with acute abdomen. Blood glucose levels are normal. SNAPcPL is abnormal. Abdominal US shows multiple hypoechoic lesions with thickened capsule in the left pancreatic limb, measuring 2-4 cm diameter. The most likely diagnosis is:
- Pancreatic pseudocyst
- Insulinoma
- Pancreatic carcinoma
- Cysts
- Pancreatic Abscess
- Metastatic hemangiosarcoma
Pancreatic Abscess
In confirming Helicobacter spp. infection of the stomach mucosa, which is the test with the best sensitivity and the quickest turn-around time?
- Endoscopic biopsy with histopathology
- Endoscopic biopsy and urease test
- Urea breath test
- Endoscopy with cytobrush for cytology
Endoscopy with cytobrush for cytology
What are two differentials for lymphocytic cholangitis in cats?
FIP, lymphoma
What is the most common cause of extrahepatic biliary obstruction in dogs?
pancreatitis
Only measurable and most reliable index of hepatic encephalopathy (HE):
ammonia
T/F: A dog that has acute abdomen, elevated ALT and abnormal cPL (SNAP) - the definitive diagnosis is acute pancreatitis
False
- The SNAP cPL has a 91% sensitivity and a 77% specificity, so a positive test should be confirmed.*
- If negative, unlikely to have acute pancreatitis*
- If positive, you should send away for quantitative test (Spec PLI)*
What is the drug of choice for treatment of large bowel IBD in the dog?
Sulfasalazine
A dog presents with an enlarged left anal gland ~2x size of the right. The animal does not appear to be systemically ill. How would you treat?
Express, lavage and infuse with topical antibiotic and steroid ointment
Which is not an end stage complication of chronic pancreatitis?
- Pancreatic acinar atrophy (PAA)
- Exocrine pancreatic insufficiency (EPI)
- Diabetes mellitus
Pancreatic acinar atrophy PAA
Ultrasonographic changes of acute pancreatitis include all, except:
- Peripancreatic hyperechogenicity
- Pancreatic hyperechogenicity
- Duodenal corrugation
- Peritoneal anechoic fluid
Pancreatic hyperechogenicity
A Doberman in Finland presents with weight loss, 2 x TN ALT, with abnormal BAS. You diagnose chronic hepatitis (CH) tentatively. What is the best course of action?
- Start liver supportive care
- Start prednisolone as Dobermans suffer from immune mediated CH
- Biopsy the liver after a PT/aPTT screen
Biopsy the liver after a PT/aPTT screen
3 month old Shar Pei. What is the diagnosis?
- Esophageal FB
- Spirocercosis
- Vascular ring anomaly
- Sliding hiatal hernia
Sliding hiatal hernia
What are the first choice analgesics used to treat pancreatitis?
buprenorphine/methadone
Breeds predisposed to chronic pancreatitis include all except:
- English Cocker Spaniel
- Eurasier
- Cavalier King Charles Spaniel
- Boxer
- Collie
Eurasier
6 month old FS dachshund. Spayed 2 weeks prior. PC: BAR but regurgitating. Most likely diagnosis?
- Idiopathic megaesophagus
- Vascular ring anomaly
- Esophageal FB
- Esophageal stricture
Esophageal stricture
What is the treatment of choice for esophageal strictures?
Balloon Dilation
T/F: The most important treatment aspect with hepatic lipidosis in cats is nutritional support
True
T/F: Trypsin‐like immunoreactivity (TLI) is very sensitive and specific for exocrine pancreatic insufficiency (EPI)
True
What drug is indicated for treatment of myasthenia gravis?
pyridostigmine
A 4-year-old German Shepherd has body odor and perineal microabscesses on inspection. What is the mainstay of therapy for this dog?
Cyclosporin
This dog most likely has perianal fistula
Is the following clinical sign more associated with small bowel diarrhea or large bowel diarrhea:
melena
small bowel
A 12 week old Boston terrier presents to your clinic with the complaint of projectile vomiting. Based on the signalment, what is the most likely diagnosis?
- Gastric lymphoma
- Gastric adenocarcinoma
- Pythiosis
- Antral pyloric stenosis
Antral pyloric stenosis
pyloric stenosis typically causes persistent vomiting in young animals (especially brachycephalic dogs and Siamese cats) but can be found in any animal. These animals usually vomit food shortly after eating. The vomiting is sometimes described as “projectile.” Animals are otherwise clinically normal, although some pets may lose weight.
A 6 week old GSD presents to your clinic with vomiting. The dog is otherwise bright, alert, with a good appetite. Based on the most likely differential, what is the most appropriate diagnostic test?
- Hematology
- Biochemistry
- Parvo fecal snap test
- Thoracic radiographs
- Echo for VSD
Thoracic radiographs