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4 Oral Biology > Salivary secretion > Flashcards

Salivary secretion Flashcards

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1
Q

where does primary saliva secretion occur?

A

acinus

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2
Q

what is primary secretion made up of?

A

water
Cl-
K+
Na+

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3
Q

initial acinar secretion
Acinar cell at rest
? pump -> ? out, ? in -> concentration ?

A

Na/K
Na
K
gradient

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4
Q

initial acinar secretion
acinar cell activated

Increase in membrane permeability to ? -> ? goes into ? and ??

Increase in ? in ?? activates ???? -> ??? go into ?

?? works ? -> no increase in ? concentration

? and ? diffuse from the ? into the ? -> changes the ?

? diffuses ? the ? from ?? to ?

? enters ? from between ? down ??

A

K
K
lumen
connective tissue

K
connective tissue
Na, K, Cl co-transporter
Na, K, Cl
cell

Na/K pump
harder
Na

Cl
K
cell
lumen
charge

Na
between
cells
connective tissue
lumen

water
lumen
cells
osmotic gradient

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5
Q

is initial acinar secretion changed by flow rate?

A

no

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6
Q

ductal modification of primary saliva occurs where?

A

in the striated ducts

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7
Q

Ductal modification of primary saliva in the striated ducts

Conversion from ? (? concentrated) to ? (? concentrated) solution

A

isotonic
more
hypotonic
less

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8
Q

Ductal modification of primary saliva in the striated ducts

Resorption of ? and ?

A

Na
Cl

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9
Q

Ductal modification of primary saliva in the striated ducts

Adds ? (?) and ? to secretion (lumen)

A

HCO
bicarbonate
K

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10
Q

Ductal modification of primary saliva in the striated ducts

Striated duct cell at rest

Impermeable to ?
??
Outside the cell high concentration of ? and ?, and low concentration of ?
Inside the cell high concentration of ? and low concentration of ? and ?

A

water
Na/K pump
Na
Cl
K
K
Na
Cl

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11
Q

Ductal modification of primary saliva in the striated ducts

Striated duct cell activated

Increased ? of ?? -> increase in ? conc. and decrease in ? conc. in the ?

? is pushed into the ? (?) to compensate

? is dragged out of the ? (?) into the ? to compensate

?? removes ?and adds ? into the ? (?)

? buffers ? changes

A

activity
Na/K pump
K
Na
cell

K
secretion
lumen

Na
secretion
lumen
cell

Cl/HCO pump
Cl
HCO
secretion
lumen

HCO
pH

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12
Q

does flow rate affect modification of saliva in the striated ducts?

A

yes

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13
Q

how does low flow rate affect modification of saliva in the striated ducts?

A

Low flow rates - > more time for passive resorption of Na

Lower Na conc. in saliva

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14
Q

how does high flow rates affect modification of saliva in the striated ducts?

A

less time for resorption of Na
- Higher Na conc. in saliva

If high flow rate, gland activity is high -> Cl/HCO pump works harder
- Increased HCO in saliva

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15
Q

most of the organic components of saliva is secreted by what?

A

acinar cells

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16
Q

secretion of organic components of saliva by acinar cells

Synthesis of proteins using ? and ? from ?

Transferred to ?? to make ?

Exocytosis of ?

A

RER
ATP
mitochondria

golgi aparatus
vesicles

vesicles

17
Q

control of secretion is by the somatic or autonomic nervous system?

A

autonomic nervous system

18
Q

remember this

Brain/spinal chord -> preganglionic neurone -> ganglion -> postganglionic neurone -> effector organ/tissue

A
19
Q

what is the function of the parasympathetic nervous system (generally)?

A

rest and digest

20
Q

parasympathetic nervous system involves neurones from where?

A

brainstem

21
Q

parasympathetic nervous system has long preganglionic or postganglionic axon?

A

long preganglionic axon

22
Q

parasympathetic signals activate the glands to produce what kind of secretion?

A

serous secretions

23
Q

what is the neurotransmitter in parasympathetic nervous system?

A

acetylcholine at synapse and released from postganglionic axon to target tissue

24
Q

what carry parasympathetic signals to the salivary glands

A

CNVII
CNIX

25
Q

CNIX takes parasympathetic fibres from the ? and ?

To the ? ganglion to lingual minor glands

or

To the otic ganglion to the ? gland

A

facial nucleus

Inferior salivary nucleus

Remak’s

parotid

26
Q

CNVII takes parasympathetic fibres from the ???

To the ?? to sublingual and submandibular gland

or

To the ?? to palatal minor salivary glands

A

Superior salivary nucleus

submandibular ganglion

pterygopalatine ganglia

27
Q

parasympathetic control of saliva secretion

? binds to ?receptor which increases permeability of ? increasing ? production of primary saliva and contraction of ??

? is an antagonist causing dry mouth

A

acetylcholine
muscarinic
K
Acinar
myoepithelial cells

atropine

28
Q

what is the function of the sympathetic nervous system (generally)?

A

fight or flight

stress response

29
Q

sympathetic signals come from neurones where?

A

in the spinal chord from T1 to L2

30
Q

sympathetic nervous system has long preganglionic or postganglionic axons?

A

long postganglionic axons

31
Q

what is the sympathetic neurotransmitter?

A

at synapse is acetylcholine

Postganglionic axon releases noradrenaline (can be ach also)

32
Q

what does the sympathetic neurotransmitter noradrenaline do?

A

increase in organic components in saliva

33
Q

sympathetic signals cause glands to produce what kind of secretion?

A

mucous

34
Q

what is Frey’s syndrome?

A

Seen after parotid surgery when damage occurs to the auriculotemporal nerve blocking parasympathetics to salivary glands and sympathetics to facial sweat glands. This results in regeneration of nerves where they can be rewired wrong so salivary stimulation e.g. eating activates sweat glands
- Gustatory sweating

4 Oral Biology (6 decks)

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