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5th Oral Disease - Other > Salivary Gland Neoplasm > Flashcards

Salivary Gland Neoplasm Flashcards

1
Q

Give examples of benign salivary gland neoplasm?

A

Pleomorphic adenoma
Warthin tumour
Basal cell adenoma

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2
Q

Give examples of malignant neoplasm?

A

Mucoepidermoid carcinoma
Adenoid cystic carcinoma
Polymorphous adenocarcinoma
Acini cell carcinoma

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3
Q

How to classify salivary gland tumours?

A

Epithelial or non-epithelial

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4
Q

Examples of epithelial salivary gland tumours?

A

Adenoms

Carcinomas

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5
Q

Where do adenomas develop?

A

In glands which secrete fluid

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6
Q

Are adenoma benign or malignant?

A

Benign

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7
Q

Where do carcinomas develop?

A

In tissue that line the inner or outer surfaces of the body

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8
Q

Where is most common site for salivary gland tumour?

A

70% parotid
Then submandibular
1% sublingual

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9
Q

Most common type salivary gland tumour?

A

70% pleomorphic adenoma

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10
Q

How often do get minor salivary gland tumour? What is issue?

A

20% in minor glands

50% are malignant

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11
Q

Where do salivary gland tumours most often present?

A

Palate

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12
Q

% of benign tumour in major glands?

A

80%

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13
Q

Example of benign epithelial neoplasm?

A

Adenoma

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14
Q

Example of adenoma?

A

Plemorphic adenoma
Warthins tumour
Basal cell adenoma

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15
Q

Give basic info about pelomorphic adenoma?

A

Most common salivary gland tumour
Often found parotid - next common site is palate
Benign

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16
Q

Common age ground for pelomorphic adenoma?

A

30-60 years

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17
Q

Histology of pleomorphic adenoma?

A

Mixed pattern- islands and strands of epithelial cells
Ductal structures
Can have myxoid, mucoid or chondroid stroma
Encapsulated
Lobular pattern

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18
Q

Where are warthin tumour found?

A

ALWAYS in parotid

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19
Q

What gender is warthin tumour more common?

A

Male 60:40

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20
Q

What see histology of war thins tumour?

A

Irregular cysts
Line onocytic duct epithelium
Stroma comprised of lymphoid tissue

21
Q

How are adenoma names?

A

According to pattern

22
Q

What is most common malignant salivary tumour?

A

Mucoepidermoid carcinoma

23
Q

Most common site mucoepidermoid carcinoma?

A

Parotid

24
Q

How many much-epidermoid carcinoma metastasise?

A

10-15%

25
Q

Histology of mucoepidermoid carcinoma?

A

Mixture of mucous and epidermoid cells
Lesions usually multi cystic
High grade lesion may be solid w/ few mucous cells

26
Q

What is second most common malignant tumour?

A

Adenoid cystic carcinoma

27
Q

Most common site for ACC?

A

Parotid

28
Q

Issue with adenoid cystic carcinoma?

A

75% pt die within 20 years - highly malignant

Metastasis via blood stream and nerve invasion

29
Q

Histology adenoid cystic carcinoma?

A

Infiltrative tumour - no capsule

Characteristic multi cystic/ cribriform pattern ‘Swiss cheese’

30
Q

What salivary gland tumour has Swiss cheese appearance?

A

Adenoid cystic carcinoma

31
Q

What salivary gland tumour is only found intra-oral?

A

Polymorphous adenocarcinoma

32
Q

Histology of polymorphous adenocarcinoma?

A

Variable histological pattern - lobules, ductal structure, cribriform areas
Perineural invasion
Infiltrative growth

33
Q

What is polymorphous adenocarcinoma often misdiagnosed as?

A

Pelomorphic adenoma

Adenoid cystic carcinoma

34
Q

What is recurrence rate of acini cell carcinoma?

A

30%

35
Q

Histological appearance acini cell carcinoma?

A

Variable; solid, microcytic, papillary cystic, follicular

Lympoid tissue and germinal centre common

36
Q

What is risk of pleomorphic adenoma becoming malignant?

A

10% become malignant

37
Q

What clinical sign would make think pelomorphic adenoma has become malignant?

A

When have hx of slow growing lesion which has recently increased in size

38
Q

Name for malignant pleomorphic adenoma?

A

Carcinoma ex plemoprhic adenoma

39
Q

Histology if plemorphic adenoma is carcinoma?

A

Typical plemorphic adenoma pattern

Area cytological atypia

40
Q

Example of tumour like lesions?

A

Onocytosis
Necrotising sialometaplasia
Salivary gland cyst
Chronic sialodenitis

41
Q

What is sjogrens syndrome?

A

Autoimmune disorder characterised by lymphocytes mediated destruction of exocrine gland

42
Q

What is seen in primary SS?

A

Dry eyes and mouth

43
Q

What is seen secondary SS?

A

Dry eye +/or mouth and connective tissue disease

44
Q

Who often presents w/ SS?

A

90% females

Middle age

45
Q

Symptoms SS?

A

Dry mouth - dry mucosa, lobulated tonuge
Infection - candidosis
Caries
Dry eyes

46
Q

Pathology of SS?

A

Lymphocytic infiltrate in salivary gland
Minor glands: focal sialodenitis
Major: lymphoepithelial lesions

47
Q

Histology SS?

A

Gland replaced by lymphocytes
Acini disappear
Duct proliferate = epithelial islands - infiltrated by lymphocytes

48
Q

What can SS lesions progress to?

A

Lymphoma

5th Oral Disease - Other (13 decks)

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