Saliva Gland

Question 1

Salivary Glands

Answer 1

Sublingual gland, parotid gland, submandibular gland

Question 2

rat salivary gland

Answer 2

down and behind ear- lacrimal gland is the in front one

Question 3

mucous cells

Answer 3

minor salivary glands and sublinguals

Question 4

serous

Answer 4

parotid gland

water and proteins, physiologic fluid

Question 5

mucos

Answer 5

minor slaivary glands and sublingual

slippery, protection

Question 6

gland diagram

Answer 6

look in notes

Question 7

saliva glands are

Answer 7

neurochemical
dual innervated
both go to more saliva produced

Question 8

sympathetic nervous system

Answer 8

T1-T3
norepi to Beta adrenergic
increased cAMP
more saliva
develops postnatal (p3-p5)

Question 9

parasympathetic nervous system

Answer 9

cranial nerves 9 and 7
IP3 and DAG
ACH to M3R
development At the same time of gland

Question 10

bicarbonate secretion

Answer 10

CO2 diffuses into cell and is combined with water to make carbonic acid, it dissociates the H+, in an activated cell bicarb leaves through secretory vesicles

Question 11

chloride mediated secretion

Answer 11

activation of a g protein (ach on m3) - more IP3- increased calcium- ion channel activation- Chlroide flows out of cell, sodium follows to keep neutral- water follows that

Question 12

h2o channels

Answer 12

aquaporin 5

Question 13

chloride channels

Answer 13

tmem16a

Question 14

straited ducts

Answer 14

pump on ions to make saliva hypotonic
na and cl out
k in
“stage 2” of saliva secretion

Question 15

protein secretion

Answer 15

beta adrenergic receptor- nor epi on g protein- cAMP- leads to vesicles dumping out protein & glycosylation and phosphorylation in ER & protein kinase in nucleus

Question 16

constitutive pathway

Answer 16

transport cell membrane protein in vesicles to cell membrane and does not require a NT

Question 17

consitutive like pathway

Answer 17

transport of secretory proteins in vesicles that bud from golgi- minimal agonist concentration

Question 18

major regulated pathways

Answer 18

rapid release of granules that fusion to the luminal cell surface
high doses of NT

Question 19

minor regulatory pathways

Answer 19

slow release of vesicles that relase from maturing secretory granules
low dose NT

Question 20

saliva functions

Answer 20

lubricate, ion reservior, buffer, clean, antimicrobial. pellice, agglutination, digestion, taste, exretion, water balance

Question 21

ectodermal dysplasia

Answer 21

can lead to non functioning saliva glands

Question 22

Sjorgrens syndrome

Answer 22

autoimmune to exocrine glands (salivary lacrmial)

Question 23

radiation can

Answer 23

kill salivary glands

Question 24

salivary gland development

Answer 24

parotid = ectoderm
sublingaul/submandibular=  unknown (mix of mesodermal and ectodermal?)
minor= mesodermal

Question 25

p63

Answer 25

marker for ectodermal organs

Question 26

prebud

Answer 26

11.5 days in mice 2-5 weeks in humans placode at specific sites in the oral cavity

Question 27

initial bud

Answer 27

12.5 days mice 6-8 weeks human expansion and invagination of the placode as an epithelial bud into a condensing mesenchyme

Question 28

pseudoglandular

Answer 28

13.5 days in mice 10 weeks in human epithelium undergoes successive rounds of branching morphogenesis, which involves cleft formation, end bud expansion, and duct elongation, finally appearing as solid end buds and cords of epithelial cells

Question 29

canalicular

Answer 29

14.5 E in mice 12 weeks in humans Branching morphogenesis continues until approximately 12 weeks where cells form a lumen and polarize appearing the lumen of the ducts and the end buds,

Question 30

terminal bud

Answer 30

17.5 E in mice 16 weeks in humans By week 16 striated and IC duct are distinguishable. From 20-24 weeks acinar cells begin to predominate

Question 31

salivary glands develop because of

Answer 31

epthelial mesenchyme interactions

Question 32

consitutive pathway

Answer 32

Proteins are continuously secreted from the cell regardless of environmental factors. No external signals are needed to initiate this process. Proteins are packaged in vesicles in the Golgi apparatus and are secreted via exocytosis, all around the cell. Cells that secrete constitutively have Golgi apparatus scattered throughout the cytoplasm. Fibroblasts, osteoblasts and chondrocytes are some of the many cells that perform constitutive secretion.

Question 33

regulative pathwaay

Answer 33

only secreted in response to a specific signal, such as neural or hormonal stimulation

Question 34

more timeline

Answer 34

Branching: 12 wks Desmosomes, serous granules and microvilli: 13-15 wks Striated and IC duct: 16 Acinar cells: 20-24 wks

Question 35

parotid gland duct

Answer 35

stensens

Question 36

submandibular duct

Answer 36

whartons

Question 37

sublingual duct

Answer 37

rivinus then bartholins