S3: Proprioceptors Flashcards
What are Proprioceptors?
They are a type of sensory receptors that monitor the movements of your own body. They are found in muscles, tendons and joints.
Two main functions of proprioceptors
- Allow you to know where your body is.
2. Provide vital feedback information for the control of our motor systems.
Describe structure of motor unit
- a-motor neurones innervate skeletal muscle (the extrafusal muscles) causing it to contract.
- These have their cell bodies in the anterior horn of the spinal cord and their axons project out to muscle where they will give a single synapse to muscle fibres.
- The a-motor neurone going down and innervating muscle fibres forms a muscle unit.
- Each AP in that motor unit will produce an AP in the muscle fibres the neurone is innervating. This causes a transient twitch in the fibres (twitches are all or nothing events).
Relationship between number of neurones to muscle fibre
A single neurone can innervate multiple muscle fibres but a single fibre can have only one nerve innervating it.
How can the force of contraction of twitches can be modified by the brain?
- Change the frequency of action potential firing in the active motor units.
- Change the number of active motor units.
- Change the type of active motor units.
Describe motor unit activity at rest
At rest, when relaxing there is a little activity going on in our muscle fibres. Small weak oxidative fibres are firing slightly producing some background tone in the muscle.
This is because there is activity in the smallest motor neurons that have the smallest and weakest motor units.
What is the general rule about the size of a neurone cell body?
The general rule is that the bigger a neurons cell body, the bigger the stimulation you have to give it to get it up to fire an action potential.
- So if there is weak excitatory input coming into a pool of motor neurones, only the smallest and weakest neurones are active.
- So smaller cells are easier to activate than big cells.
What does a pool of motor neurones mean?
A group of a-motor neurone cell bodies in the anterior horn that are involved in innervating a single muscle.
Describe how force of contraction of twitches can be increased by increasing overall excitation of motor unit pool
Increasing the overall excitation of the motor unit pool means there will have more action potentials activating more muscle fibres. This means the next easiest (and larger) neurons will be activated.
- Middle neurones activated: These are more powerful, but more fatigable e.g. this is useful in long distance running
- Largest neurones activated: Maximum excitatory input coming to motor unit pool and there is activation of the biggest motor units. These innervate large powerful fibres e.g. throwing large things.
So if we grade muscle power by increasing the amount of excitatory input onto the a-motor neurone unit pool they will automatically activate from weakest to strongest.
What 2 inputs affect whether a cell produces an AP or not?
Whether a cell produces an AP is based on the balance of excitatory and inhibitory inputs.
So if we want a weaker contraction we can have less excitation or more inhibition, this means it is a balance between excitation and inhibition.
More inhibition will switch off excitation, but if this inhibition is decreased, the smaller fibres will be first excited as they are more susceptible to being activated.
Importantly, it allows very fine control over movement.
What two things do proprioceptors monitor?
- Changes in muscle length.
2. Tension in muscle tendon.
Describe structure of muscle spindle and its fibres
- Muscle spindle is in muscle
- Spindle consists of a capsule and inside intrafusal muscle fibres
- Surrounding the outside are normal muscle fibres called extrafusal fibres
- Contractile portions are at end of intrafusal muscle fibres (actin and myosin) while the middle is just passive elastic fibres were afferent nerve fibres are found. It is stretch in the middle area that will activate the sensory afferents.
How do intrafusal muscle fibres increase excitation of a-motor neurone pool?
Intrafusal fibres are associated with sensory afferents which project to the spinal cord and are able to increase excitation of that α-motor neurone pool!
- What occurs is when there is unintended stretch of a muscle, due to the muscle contracting too little (e.g. arm/leg sagging down). The spindle gets stretched (in middle) and this will cause the sensory afferents to send signals to the spinal cord and will increase excitation of the motor neurone pool innervating that same muscle. As a result there will be increased AP firing and contraction of more and bigger myofibres and the muscle will contract with more force allowing to maintain position. This allows control of posture.
What is the difference between intrafusal muscles and extrafusal muscles?
Intrafusal muscles are those fibres inside the muscle spindle capsule which extrafusal muscles are the ordinary muscle fibres making up the bulk of the muscle.
What controls our posture?
It is our muscle spindles rather than brain! We don’t have to think about how hard it is to contract our muscles in order to control a limb in one position. We also have to make exactly the right number of motor neurones fire the right number of AP to keep a posture and it is our spindles that control this.
Describe reciprocal inhibition in the control of posture
An example is our arm:
- Biceps and triceps muscles present. a-motor neurone activates biceps.
- The muscle spindle has its afferent which makes a monosynaptic connection with the motor neurone, so if you have unintended stretch of the muscle it will reflex contract (if contraction becomes too weak to support the mass and arm sags down which stretches the muscle).
- The afferent also activates an inhibitory interneurone which suppresses activity in the motor neurone driving the antagonistic muscle - inhibits stretch reflex in anatagonist muscle.
- Therefore, when we have the unintended stretch of the biceps, the spindle will detect the stretch of muscle and send a signal to the spinal cord which increases excitation to the α-motor neurone pool (via the afferents) to the biceps to increase contraction and at the same time activate inhibitory interneurones that inhibit the α-motor neurones to the triceps, which relaxes it.
- This is because if we a reflexively contracting the biceps, the triceps need to be relaxed to allow this movement.