S15C185 - NSAID OD

Question 1

NSAID function

Answer 1

• inhibit cyclooxygenase and therefore inhibit prostaglandin production causing anti-inflammatory effect
• inhibit neutrophils
• antipyretics via inhibition of PgE
• reduce pain
• COX-1 inhibition cause unwanted SE (GIB)
• COX-2 inhibition is the desired therapeutic effect

Question 2

NSAID OD clinical picture:

Answer 2

• AMS, metabolic acidosis, shock at ingestions >400mg/kg
• Sx: abdo pain, n/v w/in 4h
• CNS: ha/, n ystagmus, diplopia, seizure (mefenamic acid), AMS
• CVS: HoTN, shock, brady
• Renal insufficiency