S15C178 - Nonbenzodiazepine sedatives

Question 1

Buspirone

Answer 1

-causes sedation but also seizures

Question 2

Chloral hydrate OD

Answer 2

• sedation w/o resp dpn at therapeutic levels
• OD: coma, cardiovascual instability, arrhythmias, PVC, V fib, torsades, asystole
• GI: n/v, hmorrhagic gastritis
• pear-like odor

Question 3

GHB

Answer 3

• gama-hydroxybutyrate
• date-rape drug
• peak plasma 30-40min
• non-detectable in urine >12h after ingestion
• Sx: sedation, seizure, coma, resp dpn, cardiac dpn, bradycardia, hypothermia, miosis/mydriasis
• tx: physostigmine, intubation