rRenal Ca Flashcards
list the main presenting features of renal cell carcinoma (3)
leukocytosis
temp spikes
hypercalcemia
whixh age group is most affected by renal cell ca
50-70
list some of the risk factors of renal cell ca
Smoking
Obesity
Acquired renal cystic kidney disease related to CRF, on dialysis
Von Hippel-Lindau disease (syndrome)
Sickle Cell Disease
what is von lindau disease
rare AD disorder characterised by development of numerous benign and malignant tumors
45% develop RCC
Present at a young age, bilateral and multiple
which renal tumour are found in the proximal convuluted tubules
Clear cell renal carcinoma (70-80%) : arises from proximal convoluted tubules
which renal cell tumours arise from the distal convoluted tubule
Papillary renal cell carcinoma (13-20%): arises from distal convoluted tubules
which renal cell tumours arise from the Intercalated cells of collecting ducts
chromophone renal cell carcinoma (5%)
best prognosis
which renal cell tumours are found in sickle cell disease
Renal medullary carcinoma: seen primarily in sickle cell disease
which genetic syndromes are associated with clear cell rcc
tuberous sclerosis complex and von hippel lindau syndrome
which type of rcc is seen in hereditary papillary rcc
type 1 papillary
which type of rcc is ass with Hereditary Leiomyomatosis & RCC Syndrome
Type 2 Papillary
which type of rcc is found in birt hogg dube syndrome
chromophobe
symptoms of renal cell carcinoma arise from what or due to what?
tumour growth
haemorrhage
paraneoplastic syndromes
list the symptoms and signs of renal cell ca
Fever
Weight loss
Night sweats
Malaise
Left Varicocele- due to obstruction of testicular vein
10% present with flank pain, flank mass and haematuria
other signs
-HPT
-Varicocele
Lymphadenopathy
-Lower limb oedema
which conditions are seen in patients with paraneoplastic syndromes?
Anaemia
Hypertension
hypercalcemia
Hepatic dysfunction “stoffels”
Cushings
Fever with night sweats
polymyalgia reumatica
