Round 2

Question 1

Acquired Polycystic Kidney Disease can lead to what disease?

Answer 1

RCC

Question 2

RCC what is the right way to diagnosis?

Answer 2

Excisional biopsy

Question 3

What is the sporadic form of RCC due to ?

Answer 3

VHL, Excisional biopsy

Question 4

VHL can lead to what?

What two locations will these two places end up?

Answer 4

Hemangioblastomas

Cerebellum and Retina

Question 5

How does RCC move through out the body?

Answer 5

Hematogenously

Question 6

What are the three neoplastic parts of RCC?

Answer 6

EPO: increased hemoglobin, renin: increased HTN, ACTH: Cushing Syndrome

Question 7

Oncocytoma is what kind of disease?

Answer 7

Benign

Question 8

Medulla: obstruction collecting ducts

Gross: few cysts in medulla, pyelonephritis and stones

What disease is this?

Answer 8

Sponge Kidney in the Medulla

Question 9

What is angiomyolipoma usually associated with?

Answer 9

Tubero Sclerosis

Question 10

Pediatric Tumor: Nephroblastoma

How is it differentiated from Neuroblastoma?

Answer 10

Nephroblastoma does not cross the midline

Neuroblastoma crosses the midline and is from the adrenal gland

Question 11

Pediatric Tumor is what?

Gross: Gray and Tan

Histo: Normal Stroma, Aboritive Tubules, and undifferentiated mesenchyme

Patient also has hypertension

Answer 11

Wilms Tumor, Nephroblastoma, however there are three different flavors

Question 12

Pediatric Tumor: Nephroblastoma

WT1 deletion has what?

Answer 12

WT1 deletion: WAGAR Syndrome

W: Wilms Tumor
A: Anirida (loss of the iris)
G: Genitourinary Anomalies
R: Retardation, Mental

Question 13

Pediatric Tumor: Nephroblastoma

WT1 mutation has what?

Answer 13

WT1 mutation: Denys Drash syndrome

Same thing as WAGR, but only W and G

W: Wilms Tumor
A: no
G: Genitourinary Anomalies
R: no

Question 14

Pediatric Tumor: Nephroblastoma

WT2 problem is?

Answer 14

WT2 problem: Beckwith-Wiedemann Syndrome

Big Baby
Hemihypertrophy
Omphalocele
Large Tongue**

Question 15

PSGN what is found in the IF biopsy?

Answer 15

Granular Pattern

IgM, IgG, and Complement

Question 16

PSGN is found 2-4 weeks after what disease?

Answer 16

Strept Pyogeneus

Question 17

IgA nephropathy is found how long after mucosal infection?

Answer 17

2 days

Question 18

Where is there IgA nephropathy deposited?

Answer 18

Mesangial Deposits

Question 19

RPGN is what?

Answer 19

Rapid Progressive Glomerulonephritis, a nephritic syndrome

Question 20

RPGN contains crescents, what is in the cresents?

Answer 20

Macrophages, fibrin

Question 21

RPGN-1 is what disease?

What is the main target/problem?

Answer 21

Good Pastures Disease

Anti-Glomerular Membrane Antibodies

Question 22

What are the big symptoms with Good Pastures Disease?

What is the immune pattern?

Answer 22

Hematuria and Hemoptysis

Linear Antibody Deposition

Question 23

What are the big symptoms with RPGN type 2, Granular pattern?

Answer 23

Lupus Nephritis, preformed antibody-antigen complex

Question 24

RPGN type 3, is mostly what underlying problem?

Answer 24

Vasculitus problems

Question 25

RPGN type 3, has C-ANCA, ENT issues and what else?

Answer 25

Hemoptysis and Hematuria

Question 26

RPGN type 3, microscopic polyangitis, does not have many underlying symptoms. What is the marker for it?

Answer 26

P-ANCA

Question 27

RPGN type 3, Churg Strauss is P-ANCA plus what two underlying problems?

Answer 27

Eosinophilia and Asthma

Question 28

Where does PSGN deposit?

Answer 28

Subepithelial humps

Question 29

What Nephrotic syndrome is not immune complex deposited and does respond to steroids?

Answer 29

Minimal Change Disease

Question 30

What Nephrotic Syndrome is not immune complex deposited and does not respond to steroids?

Answer 30

Primary Focal Sclerosing Glom. Syndrome

Question 31

Primary FSGS has a poorly understood mechanism, what are some things that can contribute to this cause?

Answer 31

HIV, Heroin, Sickle Cell

Question 32

Secondary FSGS is caused by what?

Answer 32

Glomeruli dying

Question 33

Secondary GSGS can maintain GFR, but can lead to what?

Answer 33

Interglomerular HTN, Mesangial Proliferation, Podocyte denuding

Question 34

MCD, Primary/Secondary FSGS are different from the other Nephrotic Syndromes, how?

Answer 34

No immune Deposition

Question 35

Membranoproliferative type I, Dense Deposit type II, and Membranous Nephropathy are different from other people Nephrotic Syndromes in what way?

Answer 35

Immune Deposition caused

Question 36

MPGN type 1 and type 2 both have what on light microscopy?

Answer 36

Tram Track

Question 37

MPGN type 1 is caused by what?

Answer 37

Preformed Ag-Ab complexes

Question 38

MPGN type 2 is caused by what?

Answer 38

C3 nephritic Factor and an increased C3 convertase

Question 39

MPGN type 1 deposits are where? What type of IF pattern will there be

Answer 39

Sub endothelial Granular IgG and C3

Question 40

MPGN type 2 deposits are where? What type of IF pattern will there be?

Answer 40

Split GBM Linear C3 pattern

Question 41

What is seen on Dense Deposit disease in basement membrane EM?

Answer 41

Ribbon like deposition in basement membrane

Question 42

What types of deposits are seen on membranous nephropathy?

Answer 42

Subepithelial deposits

Question 43

There are two types of deposits on membranous nephropathy: 1 is caused by what immune complex deposition?

Answer 43

PLA2 receptor podocyte immune complex deposition

Question 44

There are two types of deposits on membranous nephropathy: 2 is caused by what immune complex deposition?

Answer 44

Placed antigen from HIV, Hep B, Hep C, Syphillis, Gold, Captopril, Lung and Colon Cancer

Question 45

Membranous nephropathy IF shows what?

Answer 45

Granular patterns with IgG and C3

Question 46

Membranous nephropathy EM shows what?

Answer 46

Subepithelial Deposits