Role of Glia in Alzheimer's (RF) Flashcards
What is Alzheimer’s?
the most common form of dementia
a progressive disease with gradual decline that slowly accelerates
What are the 2 types of Alzheimer’s disease?
1- early onset (familial) 5%
2- late onset (sporadic) 95%
What are early symptoms of Alzheimer’s?
short term memory loss
What are advanced symptoms of Alzheimer’s?
long term memory loss
confusion
language impairments
personality changes
What is the macroscopic pathology of Alzheimer’s disease?
cell death
enlarged sulci (gaps)
affects neurons in temporal region
What is the microscopic pathology of Alzheimer’s disease?
uses histological staining techniques, looks at:
amyloid plaques
microglia activation
Neurofibrillary tangles
What is the main form of immune defence in CNS?
activation of microglia
What is the process of microglia going from inactive to active?
starts off as ramified microglia (inactive)
inflammatory chemicals
amoeboid microglia (active for phagocytosis)
What occurs in response to increase in activation of microglia?
Neuroinflammation
When can microglia change shape?
when active
change to neuroprotective and neurotoxic
What helps control microglia activation?
neurons
What to microglia surround?
amyloid plaques
they enlarge to engulf beta-amyloid plaques
What is Donan
