Rodgers 2-24 Flashcards
1
Q
Dyad
A
the top of the nucleosome DNA loop
2
Q
What class of proteins are chromatin remodellers? (enzymes)
A
DNA translocases
3
Q
Where do chromatin remodelers bind the nucleosome (first)?
A
at the linker region and ON the histone
4
Q
What handed-ness is the nucleosome DNA wrapped around the core protein?
A
left-handed wrap-around
5
Q
Why do poly-A sequences exclude DNA
A
Because they are so stiff, it is too energetically costly to wrap them around histone cores
6
Q
Trans- mechanism hypothesis
A
The theory that remodelling enzymes and TF’s determine the placement of nucleosomes just as much if not more than the DNA’s sequence
7
Q
What are 4 common modifications to histones
A
phosphorylation, acetylation, ubiquitination, and methylation
