Rodenticides

Question 1

Brodifacoum

Answer 1

Class: second generation hydroxycoumarin

MOA: inhibition of vitamin K epoxide reductase

Consequences: clinical bleeding from coagulopathy

Question 2

Bromadiolone

Answer 2

Class: second-generation hydroxycoumarin

MOA: inhibition of vitamin K epoxide reductase

Consequences: clinical bleeding from coagulopathy

Question 3

Chlorophacinone

Answer 3

Class: Indandione

MOA: inhibition of vitamin K epoxide reductase

Consequences: clinical bleeding from coagulopathy

Question 4

Diphacinone

Answer 4

Class: Indandione

MOA: inhibition of vitamin K epoxide reductase

Consequences: clinical bleeding from coagulopathy

Question 5

Warfarin

Answer 5

Class: First generation hydroxycoumarin

MOA: inhibition of vitamin K epoxide reductase

Consequences: clinical bleeding from coagulopathy

Question 6

Cholecalciferol

Answer 6

Class: cholecalciferol

MOA: increased GI absorption and decreased renal calcium loss

Consequences: hypercalcemia leading to acute kidney injury

Question 7

Bromethalin

Answer 7

Class: bromethalin

MOA: uncoupling of oxidative phosphorylation

Consequences: Neurologic signs from intramyelinic edema

Question 8

Zinc phosphide

Answer 8

Class: zinc phosphide

MOA: disruption of mitochondrial respiration and free radical production

Consequences: GI signs, lethargy, neurologic abnormalities, respiratory distress, cardiovascular compromise

Question 9

Strychnine

Answer 9

Class: strychnine

MOA: Prevents uptake of glycine at inhibitory synapses of Renshaw cells in the CNS (disinhibition)

Consequences: muscle contractions, convulsions, extensor rigidity, death