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Microbiology II > + RNA viruses > Flashcards

+ RNA viruses Flashcards

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1
Q

+ Strand RNA Virus Families (5)

A
  • Picornoviridae (NE)
  • Calciviridae (NE)
  • Togaviridae (E)
  • Flaviviridae (E)
  • Coronaviridae (E)
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2
Q

Picornoviridae (features, subfamilies (3))

A
  • non-enveloped +RNA viruses

- Contains groups Enterovirus, hepatovirus, rhinovirus

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3
Q

Calciviridae (features, viruses (2))

A

non-enveloped + RNA viruses

-contains Norwalk virus, Hepatitis E

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4
Q

Picornoviridae Hepatoviruses (1)

A

Hepatitis A

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5
Q

Rhinoviruses

A

Subfamily of picornaviridae

  • live at 33º since infect nose
  • common cold
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6
Q

Enteroviruses (family, viruses (4))

A

Subfamily of picornaviridae

  • includes coxsackievirus, echovirus, enterovirus, poliovirus
  • acid-stable, 37º
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7
Q

Enveloped + RNA virus families (3)

A

Togaviridae, Flaviviridae, Coronaviridae

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8
Q

Togaviridae (characteristics, subfamilies (2))

A
  • enveloped + RNA virus family, arthropod borne

- Contains alphaviruses and rubiviruses

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9
Q

Flaviviridae (characteristics, subfamilies)

A
  • enveloped + RNA virus family, arthropod borne

- contains flavivirus and Hep C subfamilies

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10
Q

Coronaviridae (characteristics, symptoms, viruses)

A
  • enveloped + RNA virus family
  • Named for glycoprotein “crown”
  • helical capsid (unlike everything else + RNA, icosahedral)
  • most cause cold, GI, asymptomatic
  • contains MERS, SARS
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11
Q

Alphaviruses (classification, viruses (4))

A

+ RNA enveloped viruses within togaviridae

  • Chikungunya
  • Eastern Equine Encephalitis Virus
  • Western Equine Encephalitis Virus
  • Venezuelan Equine Encephalitis Virus
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12
Q

Rubiviruses (classification, viruses (1))

A
    • RNA enveloped viruses within togaviridae

- Rubella

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13
Q

Flaviviruses (classification, viruses (7))

A
    • RNA enveloped viruses within Flaviviridae
  • Dengue fever virus
  • Japanese encephalitis virus
  • St Louis Encephalitis virus
  • Tickborne encephalitis virus
  • West Nile Virus
  • Yellow Fever Virus
  • Zika Virus
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14
Q

Picornaviridae replication cycle (polio as ex)

A

picornavirus, non-enveloped icosahedral + RNA virus

  • VP1,2,3,4
  • VPg instead of 5’ cap on viral RNA
  • IRES (internal ribosomal entry site) in 5’ UTR allows translation without 5’ cap
  • one RNA, so one ORF, one polyprotein transcript, viral proteases cleave (and disable normal host cellular transcription)
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15
Q

Poliovirus (class, infection)

A

picornaviridae

-fecal-oral spread, mostly GI asymptomatic. Rarely viremia, more rarely CNS spread to cause poliomyelitis

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16
Q

Coxsackievirus (classification, disease, symptoms)

A

-+ strand RNA enterovirus (picornaviridae)
Common in kids- hand/foot/mouth disease
-in immunocompromised adults, meningitis rash and conjunctivitis

17
Q

Echovirus (classification, disease symptoms)

A
    • strand RNA enterovirus (picornaviridae)

- meningitis, conjunctivitis, rash (like coxsackie virus) + diarrhea

18
Q

Enterovirus (classification, symptoms)

A
    • strand RNA enterovirus (picornaviridae)

- GI symptoms

19
Q

Flavivirus vs togavirus

A

F: one ORF, polypeptide, structural genes at 5’ end
T: two ORFs, structural is subgenomic, at 3’ end

20
Q

Alphavirus (EEEV, WEEV, VEEV, Chikungunya)

A
    • RNA enveloped togavirus subfamily
  • accidentally transferred to humans by mosquito, cause flu-like symptoms
  • Chikungunya cause arthritis-like
21
Q

Rubivirus

A
    • RNA enveloped togavirus subfamily

- Causes Rubella: respiratory transmission, fever malaise rash. Causes congenital malformations in first trimester

22
Q

West Nile Virus (classification, symptoms, rare symptoms)

A

Flavivirus, +RNA enveloped flaviviridae transmitted by mosquitos

  • Asymptomatic (80%), causes fever, headaches, fatigue, rash, myalgia, nausea,
  • rarely Guillan-Barre, encephalitis, paralysis
23
Q

Dengue Fever (classification, symptoms, rare symptoms)

A

Flavivirus, +RNA enveloped flaviviridae transmitted by mosquitos

  • “Breakbone Fever”- fever, rash, BONE AND JOINT PAIN, lymphadenopathy. Lasts months but not fatal. 10% lead to
  • “Dengue Hemorrhagic Fever”: shock + hemorrhage (due to 4 serotypes, Ab from one bind another but dont neutralize, coat, form immune complex, type III hypersensitivity
24
Q

Yellow Fever

A

Flavivirus, +RNA enveloped flaviviridae transmitted by mosquitos

  • JAUNDICE, fever, headache, myalgia. Shock and UGI bleeds if spread to organs
  • 2 types: jungle (accident from monkeys) and urban (human) yellow fever
25
Q

Zika Virus (classification, symptoms)

A

Flavivirus, +RNA enveloped flaviviridae transmitted by mosquitos

  • asymptomatic or mild (fever, rash, arthralgia, conjunctivitis)
  • microcephaly, brain defects in fetuses
26
Q

Hepatitis C

A

Flavivirus, +RNA enveloped flaviviridae

  • Transmitted by contaminated blood, sexually, IV drugs
  • 25% acute hepatitis, many lead to chronic infection, cirrhosis. Can lead to hepatocarcinoma
27
Q

SARS, MERS (classification, symptoms)

A

+RNA enveloped virus, coronaviridae

  • severe acute respiratory syndrome, pneumonia
  • MERS same but middle east instead of china
28
Q

Norwalk Virus (classification, symptoms)

A

Caliciviridae + RNA virus

  • causes epidemic gastroenteritis 24-48 hours, common in enclosed areas like cruise ships.
  • distinguish from rotavirus since mainly adults, not infants

Microbiology II (7 decks)

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