RNA's in gene regulation and disease Flashcards
What do ncRNAs do
roles in tanscriptional and post transcriptional regulation of gene expression.
What RNA types are found both in nucleus and cytoplasm
miRNA, siRNA, cRNA
What do long non-coding RNA’s do?
Enhance or suppress gene expression
Are siRNA generated ad hoc or for a specific target
siRNA are generated ad hoc
What do siRNA’s do
specifically target particular mRNA for degradation
What does erythromycin do
blocks translocation of peptidyl-tRNA from A to P site
How are miRNA’s made
specifically encoded rather than ad hoc
What RNA types are found in the cytoplasm only
piRNA (affect transcript stability or translation)
What does rifamycin do
inhibits RNA polymerase
What do tetracyclines do
block binding of aminoacyl-tRNA to A site
What RNA types are found in the nucleus only
lncRNA, eRNA, cRNA (any affecting chromatin structure, function or transcription)
What does chloamphenicol do
Block peptidy transferase
