RNA Expression, Splicing, and Nucleotide Expansion

Question 1

Clinical features of Huntington’s

Answer 1

Chorea…dementia

Question 2

Huntington’s dz pathology

Answer 2

Subcorticol degeneration, initially centered in the striatum

Question 3

Huntington’s mutation

Answer 3

Dominant - HHT Chromosome 4

Question 4

Huntington dz protein found in the

Answer 4

Nucleus

Question 5

Huntington’s dz caused by expansion

Answer 5

Of track of glutamines close to N-terminus

Question 6

Expansion vs. contraction

Answer 6

Expansion on new strand

Contraction on old strand