Rheumatology ICM

Question 1

Which Ix is the most specific in the diagnosis of rheumatoid arthritis?

Answer 1

Anti-CCP

Question 2

Blood tests done for a pt suspected of having rheumatoid arthritis?

Answer 2

FBC, ESR/CRP, RF, ANA, RF

anti-CCP

Question 3

What imaging can be done in suspected rheumatoid arthritis? What are the findings?

Answer 3

XR

bone erosions

Question 4

What investigations are done for SLE?

Answer 4

ANA = positive
anti- dsDNA= positive
Complement (C3&4) = low
anti-smith = positive

Question 5

Which blood test specific to SLE?

Answer 5

anti-dsDNA

anti-smith

Question 6

What is ANA?

When is it positive/elevated?

Answer 6

a non specific marker of autoimmune disease

present in:

• SLE
• RA
• Sjogren’s
• Systemic sclerosis

Question 7

What is Rheumatoid factor?

When is it detected?

Answer 7

a non-specific marker of autoimmune disease

not elevated in all rheumatoid arthritis pts

elevated in....
- RA 
- SLE
- Sjogren's 
sometimes also in healthy pts

Question 8

specific test for scleroderma?

Answer 8

scl-70

Question 9

specific test for Sjogren’s?

Answer 9

Ro(SSA)/La(SSB)

Question 10

What rheumatological/ortho conditions are associated with HLA-B27?

Answer 10

ankylosing spondylitis
reiter’s syndrome/reactive arthritis
IBD