Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Final Year Defintions > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

What are the criteria for diagnosis for GCA and how many do you need to mail a diagnosis?

A

Symptoms - jaw claudication, scalp tenderness, headaches

Investigations - positive temporal artery biopsy (skip lesions), raised ESR (with normal Hb)

3 of the 5 are required for positive diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the XR findings in osteoarthritis?

A

Loss of joint space
Osteohpytes
Subchondral cysts
Subchondral sclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the XR findings in rheumatoid arthritis?

A 
Loss of joint space
Soft tissue swelling
Periarticular osteopenia
Deformity 
Subluxation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the XR findings in gout?

A

Soft tissue swelling

Periarticular erosions - “punched out erosions”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

List the 4 signs of active rheumatological disease (i.e. active inflammation)

A

Early morning stiffness
Boggy swelling
Red hot joints
Tender to palpation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name some of the deformities found in rheumatoid hands

A 
Swan neck 
Boutonniere's 
Z-thumb
Ulnar deviation of fingers 
Dorsal subluxation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

List some of the features of rheumatoid arthritis

A 
Arthritis - symmetrical, deforming inflammatory polyarthritis (affects PIPs first)
Nodules - often on elbows
Tenosynovitis
Autoimmune associations 
Pericarditis 
Carpal tunnel syndrome
Reynauld's
Felty's syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is Felty’s syndrome?

A

Triad of: rheumatoid arthritis, splenomegaly and neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Name some of the deformities found in osteoarthritis hands

A

Heberden’s nodes (distal)

Bouchard’s nodes (proximal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

List some drugs that can cause gout (HINT: think CANT LEAP)

A 
Cyclosporin
Alcohol
Nicotinic acid 
Thiazide diuretics
Loop diuretics
Ethambutol
Aspirin
Pyrazinamide
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

On polarised light microscopy, what is the difference between gout and pseudogout?

A

Gout - negatively birefringent needle-shaped crystals

Pseudogout - positively birefringenet rhomboid-shaped crystals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

List the three classical symptoms of Reiter’s disease (reactive arthritis)

A

Urethritis (can’t pee)
Uveitis (can’t see)
Arthritis (can’t climb a tree)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which CTDs are RF (rheumatoid factor) positive?

A

Rheumatoid arthritis
Sjogren’s syndrome
Felty’s disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which CTDs are ANA (antinuclear antigen) positive?

A

SLE

Sjogren’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which CTD is dsDNA positive?

A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which CTD is centromere positive?

A

CREST syndrome (limited systemic sclerosis)

17
Q

Which CTDs are Ro positive?

A

SLE

Sjogren’s

18
Q

Which CTDs are La positive?

A

SLE

Sjogren’s

19
Q

Which CTD is Sm positive?

A

SLE

20
Q

Which CTD is RNP positive?

A

SLE

21
Q

Which CTDs are Jo-1 positive?

A

Polymyositis

Dermatomyositis

22
Q

Which CTD is Scl70 positive?

A

Diffuse systemic sclerosis

23
Q

Which CTD is RNA pol positive?

A

Diffuse systemic scleorisis

24
Q

Which autoantibodies are found in SLE?

A 
dsDNA
ANA
Ro
La
Sm
RNP
25
Q

Which autoantibodies are found in RA?

A

RF
Anti-CCP
ANA

26
Q

Which autoantibodies are found in Sjogren’s?

A

RF
ANA
Ro
La

27
Q

Which autoantibodies are found in poly/dermatomyositis?

A

Jo-1

28
Q

Which autoantibodies are found in diffuse systemic sclerosis?

A

Scl70

RNA polymerase

29
Q

Which autoantibodies are found in limited systemic sclerosis (CREST syndrome)?

A

Centromere

30
Q

List the classical symptoms of Sjogren’s

A

Dryness - dry eyes, dry mouth, vaginal dryness etc.

31
Q

Outline the colour change seen in Raynaud’s hands

A

White –> Blue –> Red (crimson)

32
Q

List the features of limited systemic sclerosis

A 
Calcinosis
Raynaud's 
Esophageal dysmotility (GORD)
Sclerodactyly
Telangiectasia
33
Q

What are the signs of active disease in SLE (i.e. which markers are altered in active SLE)?

A

High ESR (high CRP would mean infection)
LOW C3, C4
High dsDNA titre

34
Q

What is the major diagnostic feature of idiopathic inflammatory myopathies (eg: polymyositis and dermatomyositis)?

A

Progressive, symmetrical proximal muscle weakness

35
Q

Name the three ANCA positive vasculitidies

A

Granulomatous polyangitis (Wegener’s)
Churg-Strauss
Microscopic polyangitis

36
Q

Which vasculitidies are cANCA positive?

A

Granulomatous polyangitis (Wegener’s)

37
Q

Which vasculitidies are pANCA positive?

A

Churg-Struass

Microscopic polyangitis

38
Q

Which antibodies are found in Goodpastures syndrome?

A

Anti-GBM (glomerular basement membrane)

Final Year Defintions (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions