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Musculoskeletal System > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Pannus

A

inflamed granulation tissue, seen in RA. Contains blood vessels, fibroblasts, and myofibroblasts (causes dragging of joint in odd directions). Also causes destruction of the cartilage

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2
Q

Morning stiffness that improves with activity

A

RA

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3
Q

Symmetric joint involvement

A

RA

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4
Q

HLA-DR4 association

A

RA

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5
Q

Rheumatoid Nodules

A

central zone of necrosis surrounded by epithelioid histiocytes

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6
Q

RF

A

IgM against Fc portion of IgG

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7
Q

Complications of RA

A

Anemia of chronic disease, secondary amyloidosis, osteopenia

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8
Q

HLA-B27 association

A

seronegative spondyloarthropathies

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9
Q

Ankylosing Spondyloarthritis

A

SI joints and spine involved, young adults esp males, low back pain, bamboo spine, uveitis, aortitis leading to regurgitation

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10
Q

Reiter Syndrom

A

Triad of arthritis, urethritis, conjunctivitis, young adults esp males weeks after GI or chlamydia trachomatis infection

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11
Q

Psoriatic Arthritis

A

Seen in 10% of patients with psoriasis, involves axial and peripheral joints, “sausage” fingers/toes due to involvement of DIP joints in hands and feet.

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12
Q

anti-CCP

A

RA

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13
Q

anti-centromere

A

CREST (limited systemic sclerosis)

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14
Q

anti-Jo1

A

polymyositis/dermatomyositis

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15
Q

anti-Scl70

A

systemic sclerosis

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16
Q

anti-RNA polym (U3 RNP)

A

systemic sclerosis, especially with renal crisis

17
Q

anti-U1 RNP

A

mixed CT disease

18
Q

anti-Smith anti-dsDNA

A

Lupus

19
Q

anti-nuclear ANA

A

Lupus + many others

20
Q

anti-Ro (SSA) anti-La (SSB)

A

Sjogren, neonatal lupus, subcutaneous lupus

21
Q

anti-MPO (P-ANCA)

A

microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

22
Q

anti-proteinase 3 (C-ANCA)

A

granulomatosis with polyangiitis (Wegener’s)

23
Q

“pencil in cup” deformity

A

psoriatic arthritis

24
Q

Telescoping digits

A

psoriatic arthritis - arthritis mutilans

25
Q

PsA compared to RA

A

more TNF alpha, IL1 beta, IL2, IL10, INF gamma. Less IL4, IL5 and less lining layer thickness but more vascularity. Also has IL18

26
Q

HLA DQ2 or DQ8 association

A

Celiac Disease

Musculoskeletal System (9 decks)

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