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PLAB 1 FEB 2025 > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Specific autoantibody for SLE

A

Anti-ds DNA antibody

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2
Q

Sensitive autoAb for SLE

A

ANA

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3
Q

Autoantibody for drug induced lupus

A

Anti histone antibody

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4
Q

Autoantibody for diffuse scleroderma

A

Anti-scl 70

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5
Q

Autoantibody for limited scleroderma

A

Anti centromere

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6
Q

CREST SYNDROME

A

Limited scleroderma
C Calcinosis
R Raynauds phenomenon
E Esophageal dysmotility
S Sclerodactyly
T Telangiectasia

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7
Q

Autoantibody in polymyositis

A

Anti-Jo1

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8
Q

Autoantibody in sjogrens syndrome

A

Anti-Ro
Anti-La

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9
Q

Autoantibody for churg Strauss syndrome

A

P-ANCA

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10
Q

Autoantibody for GPA (WEGENERS)

A

C-ANCA

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11
Q

Autoantibody in Rheumatoid arthritis

A

Rheumatoid factor (initial)
Anti - CCP (most specific)

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12
Q

Autoantibody for celiac disease

A

Anti tissue glutaminase
Anti gliadin
Anti endomysial

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13
Q

Autoantibody for primary biliary cirrhosis and Autoimmune hepatitis

A

Anti mitochondrial
Anti smooth muscle

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14
Q

SLE TREATMENT

A

Hydroxychloroquine
NSAIDS
PREDNISOLONE (SEVERE CASES)
CYCLOPHOSPHAMIDE (LIFE THREATENING LUPUS NEPHRITIS& VASCULITIS)

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15
Q

SLE PRESENTATION (13)

A

1.Low grade Fever
2.Fatigue
3.Mouth ulcers
4.Malar rash (butterfly rash)
5 Photosensitivity(discoid rash)
6.Raynauds phenomenon
7.Arthralgia
8.Myalgia
9.Polyarthritis
10.Libmann sacks endocarditis
11.Pleuritis
12.Pericarditis
13.Glomerulonephritis

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16
Q

C3 and C4 levels in SLE

A

Reduced

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17
Q

Drug induced lupus

A

Hydralazine
Chlorpromazine
Isoniazid

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18
Q

Chronic fatigue syndrome also known as

A

Myalgic encephalitis

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19
Q

Post exertional malaise or
Activity induced muscle fatigue is seen in

A

Chronic fatigue syndrome

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20
Q

Chronic widespread diffuse pain in the joint and muscles
Morning stiffness
Exacerbated in response to pressure

A

Fibromyalgia

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21
Q

Raised serum creatinine kinase with anti jo 1 antibody
Symmetrical Diffuse muscle weakness

A

Polymyositis
Treatment steroids

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22
Q

Raised serum creatinine kinase
ANA
Muscle weakness
Skin manifestations like heliotrope rash,Gottrons papules,shawl sign

A

Deematomyositis

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23
Q

Raised serum creatinine kinase
ANA
Muscle weakness
Skin manifestations like heliotrope rash,
Gottrons papules,shawl sign

A
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24
Q

Heliotrope rash (bluish purple discoloration on the upper eyelids with periorbital edema)seen in

A

Deematomyositis

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25
Q

Gottrons papules (purple red scaly rashes over extensor surfaces of joints and fingers)seen in

A

Deematomyositis

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26
Q

Pain and morning stiffness
Difficulty getting out of bed
With raised ESR and CRP

A

Polymyalgia rheumatica

27
Q

Polymyalgia vs myositis

A

Myositis (weakness > pain) with raised CK
Polymyalgia (pain> weakness) with normal CK

28
Q

Giant cell arteritis or temporal arteritis
Is a/w

A

Polymyalgia rheumatica

29
Q

Headache
Scalp tenderness
Jaw claudication
Transient visual field loss

A

Temporal arteritis
Treatment: high dose prednisolone

30
Q

Parotid and lacrimal gland enlargement
Dey eyes dry mouth

A

Sjogrens syndrome

31
Q

Eye drop to treat dry eyes

A

Hypromellose

32
Q

Abnormal growth of connective tissue
Increased fibroblast activity

A

Systemic sclerosis

33
Q

Thickening of skin
Raynauds phenomenon
Renal crisis is seen in

A

Diffuse scleroderma

34
Q

Seronegative spondyloarthritis
PAIR B

A

P PSORIATIC ARTHRITIS
A ANKYLOSING SPONDYLITIS
I IBD ASSOCIATED ARTHRITIS
R REITERS SYNDROME
B BEHCETS DISEASE

35
Q

Predominantly involve axial and peripheral joints
A/w HLA B27

A

Seronegative spondyloarthritis

36
Q

Recurrent oral and genital ulcers
Anterior or posterior uveitis / retinal vasculitis
Pathergy / erythema nodosum

A

BEHCETS disease

37
Q

Yound males
Back pain
Morning stiffness
Pain improves with activity
Anterior uveitis
Xray sacrilitis

A

ANKYLOSING SPONDYLITIS
Treatment:
Physiotherapy
NSAIDS
Oral corticosteroids
Etanercept and Adalimumab(severe)

38
Q

Can’t see
Can’t pee
Can’t climb a tree

A

REITERS arthritis

39
Q

Conjunctivitis
Urethritis
Arthritis

A

Reactive / REITERS arthritis

40
Q

M/c/c for reiters syndrome

A

C. Pneumoniae
C. Trachomatis
Occurs 2-4 weeks after a GU or GI infection

41
Q

Risk factors for gout

A

Diet with meat and alcohol
Ckd
Diuretics
Tumour cell lysis (chemotherapy)

42
Q

Treatment for acute gout

A

NSAIDS
Colchicine
Corticosteroids

43
Q

Treatment for prevention of gout

A

Allopurinol
Reduces the formation of uric acid

44
Q

Septic arthritis is caused by

A

S aureus

45
Q

Acute severe joint pain
Warmth erythema tenderness and Swelling of joints

Limited ROM
Fever

A

Septic arthritis

46
Q

Investigation and treatment of septic arthritis

A

Joint aspirations and IV antibiotics (flucloxacillin)

47
Q

Bone pain
Reduced s. Ca , s. Po4
Increased ALP

A

Osteomalacia

48
Q

Tenosynovitis of Extensor pollicis brevis
And Abductor pollicis longus

A

De Quervains disease

49
Q

Eosinophilic granulomatosis with polyangitis

A

Churg Strauss disease

50
Q

PAVE churg Strauss syndrome

A

P-ANCA
ASTHMA
VASCULITIS -BIOPSY
EOSINOPHILIA INCREASED IGE

NASAL POLYPS
PURPURA
GLOMERULONEPHRITIS

51
Q

Chronic sinusitis
Nasal crusting
Saddle nose deformity
Haemoptysis
Dyspnea
Epistaxis
Hematuria

A

Granulomatosis with polyangitis

52
Q

Saddle nose deformity
Gummas
Aneurysm
Tabes dorsalis

A

Neurosyphilis

53
Q

Necrotizing inflammation of the medium sized arteries

A

Polyarteritis nodosa

54
Q

Mononeuritis multiplex
Skin manifestations
Abd pain pancreatitis
Myalgia arthralgia
Headache fever weight loss

A

Polyarteritis nodosa

55
Q

Rheumatoid arthritis deformity

A

Swan neck and boutonniere deformity

56
Q

DMARDS

A

Methotrexate
Sulfasalazine
Leflunomide
Hydroxychloroquine

NSAIDS for acute RA and corticosteroids for flares

57
Q

Dry mouth
Enlarged parotid and lacrimal gland
D/t sarcoidosis tb or lymphoma

A

Miculicz syndrome

58
Q

Lofgrens syndrome

A

BHL
En
Polyarthralgia
Fever

59
Q

Lofflers syndrome

A

Eosinophilic accumulation in lung in response to a parasitic infection

60
Q

Heerfordt syndrome

A

Uveitis secondary to sarcoidosis
Parotid enlargement
Fever

61
Q

Ray loves knives

A

Raynauds phenomenon
Treatment Nifedipine

62
Q

Major criteria
Rheumatic fever

A

Subcutaneous nodules
Pan carditis
Arthritis (polyarthritis)
Chorea
Erythema marginatum

63
Q

Minor criteria for rheumatic fever

A

Fever
Arthralgia
Previous RH or RHD
Increased ESR or CRP
Prolonged PR interval in ECG

PLAB 1 FEB 2025 (8 decks)

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