Rheumatology

Question 1

What are the lab features of macrophage activation syndrome in sJIA?

Answer 1

Ferritin >684 and any 2 of the following:

• Plts =181 (low)
• AST >48
• TGs >156 (high)
• Fibrinogen =360 (high)

Question 2

What are the features of macrophage activation syndrome?

Answer 2

• Constant fever
• Thrombocytopenic purpura
• CNS HLH encephalopathy
• Pancytopenia
• HIGH ferritin
• low fibrinogen
• HIGH TGs
• high liver enzymes

Question 3

What medications may be used for macrophage activation syndrome?

Answer 3

IV methylprednisolone pulse
Anakinra
Cyclosporine
Etoposide