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Internal Medicine > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Management for scleroderma renal crisis (Hypertensive emergency, headache, MAHA, Thrombocytopenia, elevated serum creatinine levels, and proteinuria)

A

ACE inhibitors, typically captopril

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2
Q

Most common side effect of topical NSAID

A

Skin irritation/rash

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3
Q

Autoimmune disease that has clinical manifestations of other specific connective tissue diseases, but not enough positive features to satisfy diagnostic or classification criteria for any one disease

it’s appropriate treatment

A

Undifferentiated connective tissue disease; hydroxychloroquine

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4
Q

Nongranulomatous necrotizing pauci-immune vasculitis of small vessels or pauci-immune necrotizing crescenteric glomerulonephritis in the kidney

A

Microscopic polyangiitis

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5
Q

Strongest modifiable risk factor for osteoarthritis

A

Obesity

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6
Q

Non-inflammatory condition that involves ossification of spinal ligaments and entheses and usually presents as back pain and stiffness; characteristic radiographic changes include confluent ossification of at least for continuous vertebral levels, usually on the right side of the spine

A

Diffuse idiopathic skeletal hyperostosis

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7
Q

Recommended agent for patients with severe recurrent and/or tophaceous gout that is intolerant or resistant to standard therapies

A

Pegloticase

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8
Q

Appropriate diagnostic test for suspected chlamydial reactive arthritis

A

Nucleic acid amplification urine testing

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9
Q

Inflammatory back pain for 3 months or more and bilateral sacroiliitis on imaging

A

Ankylosing spondylitis

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10
Q

Secondary cause of acute and chronic GI bleeding in patients with diffuse cutaneous systemic sclerosis (*hint: watermelon sign)

A

Gastric antral vascular ectasia

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11
Q

Treatment for severe and refractory gout attacks or with contraindications to other treatments

A

Anakinra

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12
Q

Treatment for refractory undifferentiated connective tissue disease

A

Hydroxychloroquine

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13
Q

Combination of this medication and methotrexate has shown efficacy in managing joint symptoms and slowing the progression of radiographic damage, including joint space narrowing and erosion in recalcitrant/uncontrolled psoriatic arthritis

A

TNFa inhibitor (I.e. Abatacept)

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14
Q

Three drugs FDA approved for fibromyalgia

A

Pregabalin, duloxetine, milnacipran

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15
Q

Interstitial lung disease, myositis, Raynaud phenomenon, nonerosive inflammatory arthritis, constitutional findings such as low-grade fever and mechanics hands; anti-Jo-1 antibody positive

A

Antisynthetase syndrome

+anti-aminoacyl-tRNA synthetases antibodies, I.e. anti-Jo-1

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16
Q

Rare but severe presentation of SLE characterized by shortness of breath, hypoxia, and diffuse pulmonary infiltrates

A

Lupus pneumonitis

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17
Q

Long-standing aggressive rheumatoid arthritis, neutropenia, and splenomegaly with the risk for serious infections, lower extremity ulcers, lymphoma, and vasculitis

A

Felty syndrome

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18
Q

Vasculitis affecting medium sized arteries and is characterized by constitutional and neurologic symptoms, skin rashes, and kidney involvement that is renovascular rather than glomerular in origin

A

Polyarthritis nodosa

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19
Q

Inflammatory myopathy that can involve both the proximal and distal muscles with typically symmetric muscle distribution

A

Inclusion body myositis

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20
Q

Initial management of Sjogren syndrome

A

Restoring moisture of the eyes and mouth (I.e. artificial tears and sugar-free candies)

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21
Q

Eye pain, pain with gentle palpation of the globe, photophobia, vision-threatening in a patient with RA

A

Scleritis

22
Q

Triad of tenosynovitis, dermatitis (usually painless pustular or vesiculopustular lesions), and polyarthralgia without frank arthritis

A

Arthritis-dermatitis syndrome of disseminated gonococcal infection due to neisseria gonorrhea

23
Q

Appropriate treatment for patients who experience a relapse of GPA

A

Rituximab

24
Q

Appropriate treatment for primary angiitis of the CNS

A

Cyclophosphamide + high-dose glucocorticoid

25
Q

Acute onset of small-joint symmetric Polyarthritis following a febrile illness with a rash, in those with exposure to children

A

Parvovirus B19 infection

26
Q

Spiking fever, and evanescent salmon-colored rash on the trunk and extremities that occurs in conjunction with fever, arthritis, LAD, leukocytosis, and high serum ferritin level

A

Adult-onset Stills disease

27
Q

Most appropriate test to perform to diagnose chronic inflammatory monoarthritis

A

Synovial biopsy

28
Q

Myopathy associated with Anti-HMG Co-A reductase antibodies

A

Immune-mediated necrotizing myopathy

29
Q

Most appropriate diagnostic test to confirm suspected Sjögren syndrome in a patient with uninformative serologic evaluation

A

Lip biopsy

30
Q

Inflammatory condition affecting the bursa at the insertion of the conjoined medial knee tendons into the anteromedial proximal tibia

A

Pes anserine bursitis

31
Q

Inflammation and damage of cartilaginous tissues (i.e. external and middle ear, nose, tracheobronchial tree, and joints)

A

Relapsing polychondritis

32
Q

Appropriate treatment for gouty cellulitis accompanying an attack of acute gouty arthritis

A

Prednisone

33
Q

Set an onset of pain, warmth, tenderness, and swelling of the affected joint, usually a knee or wrist, + chondrocalcinosis

A

Acute calcium pyrophosphate crystal arthritis (pseudogout)

34
Q

Systemic sclerosis + AKI and severe hypertension, mild proteinuria, UA with few cells or casts, MAHA, thrombocytopenia

A

Scleroderma renal crisis

35
Q

Recurrent painful oral and genital mucosal ulcerations, inflammatory eye disease, pathergy

A

Bechet Syndrome

36
Q

Acute arthritis, bilateral hilar LAD, erythema nodosum

A

Lofgren syndrome

37
Q

Diagnosing IgA vasculitis

A

Biopsy of affected organ

(Biopsy will demonstrate leukocytoclastic vasculitis with predominance of IgA deposits on immunofluorescence

38
Q

Most appropriate initial immunosuppressive therapy in the treatment of isolated class V lupus nephritis, especially without kidney dysfunction

A

Mycophenolate mofetil

39
Q

Diagnostic test of choice to assess and categorize kidney disease in patients with SLE

A

Kidney biopsy

40
Q

Causes of premature mortality in patients with mixed connective tissue disease

A

Pulmonary arterial hypertension and interstitial lung disease

41
Q

FDA approved as an addition to standard therapy in patients who have SLE with persistent mild to moderately active disease

A

Belimumab

42
Q

Confluent ossification of at least 4 contiguous vertebral levels, usually on the right side of the spine

A

Diffuse idiopathic skeletal hyperostosis (DISH)

43
Q

Alternative to colchicine for recurrent oral ulcers in Bechet syndrome

A

Aprelimast

44
Q

First-line treatment of familial Mediterranean fever

A

Lifelong daily prophylaxis with colchicine

45
Q

Recommended management for urate-lowering therapy in patients who have contraindications to allopurinol

A

Febuxostat

46
Q

Pharmacological management for oral dryness in Skogren syndrome not relieved with non-pharmacological therapy

A

Cevimeline or pilocarpine

47
Q

Annular and polycyclic photosensitive plaques on the back, chest, extremities, or psoriasiform scaly plaques in a similar distribution

A

Subacute cutaneous lupus erythematosus

48
Q

Main state of therapy for ILD in systemic sclerosis

A

Mycophenolate mofetil

49
Q

Treatment for IgG4 related disease

A

High-dose glucocorticoids and rituximab

50
Q

First line treatment for new diagnosis of Rheumatoid arthritis

A

Methotrexate

Internal Medicine (12 decks)

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