Rheumatoid Arthritis

Question 1

1. Rheumatoid arthritis most frequently develops in:
   a. Adolescent females
   b. Adolescent males
   c. Middle-aged women
   d. Middle-aged men

Answer 1

c. Middle-aged women

Question 2

2. Worldwide the incidence of rheumatoid arthritis is:
   a. 1% to 2%
   b. 2% to 4%
   c. 5% to 10%
   d. More than 10%

Answer 2

a. 1% to 2%

Question 3

3. Women are _______ likely than men to develop rheuma-
   toid arthritis.
   a. Less
   b. Equally
   c. Two to three times more
   d. 10 to 20 times more

Answer 3

c. Two to three times more

Question 4

4. Rheumatoid factor is defined as:
   a. Antigens with specificity for antibody determinants
   on the Fc fragment of human or certain animal IgG
   b. Antibodies with specificity for antigen determinants
   on the Fc fragment of human or certain animal IgG
   c. Antigens with specificity for antibody determinants
   on the Fc fragment of human or certain animal IgD
   d. Antibodies with specificity for antigen determinants
   on the Fc fragment of human or certain animal IgD

Answer 4

b. Antibodies with specificity for antigen determinants
on the Fc fragment of human or certain animal IgG

Question 5

5 and 6. The principle of the rapid agglutination test is based
on the reaction of patient (5) _______ and (6)_______
derived from gamma globulin.
a. Antigen
b. Antibody
c. Complement levels
d. Leukocytes

Answer 5

5. b
6. a

Question 6

7-9. Arrange the steps in the pathogenesis of rheumatoid
arthritis in the proper order.
7. _______
8. _______
9. _______
a. Immunologic events perpetuate the initial inflamma-
tory reaction.
b. The primary etiologic factor initiates synovitis.
c. An inflammatory reaction in the synovium develops
into a proliferative destructive process of tissue.

Answer 6

7. b
8. a
9. c

Question 7

10. All the following are criteria for rheumatoid arthritis
    except:
    a. Morning stiffness
    b. Evening stiffness
    c. Rheumatoid nodules
    d. Radiographic changes

Answer 7

b. Evening stiffness

Question 8

11. RF correlates with all the following except:
    a. The severity of the disease in general
    b. The presence of nodules
    c. Other organ system involvement (i.e., vasculitis)
    d. The age of the patient

Answer 8

d. The age of the patient

Question 9

12. In RA, vascular and parenchymal lesions suggest that
    lesions result from injury induced by immune complexes,
    especially those containing antibodies to:
    a. IgM
    b. IgG
    c. IgE
    d. IgD

Answer 9

b. IgG

Question 10

13. Serum complement levels are usually _______ in patients
    with rheumatoid arthritis.
    a. Normal
    b. Decreased
    c. Increased
    d. a or b

Answer 10

a. Normal

Question 11

14. The most common form of juvenile idiopathic arthritis is:
    a. Systemic
    b. Oligoarthritis
    c. Psoriatic
    d. Enthesitis-related

Answer 11

b. Oligoarthritis

Question 12

15. In the RF agglutination procedure, a false-positive result
    may be observed in a serum specimen because of:
    a. Complement interference
    b. High levels of C-reactive protein (CRP)
    c. Antigen excess
    d. Hemolysis

Answer 12

d. Hemolysis

Question 13

16. In rapid testing for rheumatoid factor, biological false-
    positive results can be caused by a variety of disorders
    including:
    a. Infectious mononucleosis
    b. Hepatitis
    c. Systemic lupus erythematosus
    d. Either b or c

Answer 13

d. Either b or c