Autoimmune Disorders Flashcards
- All the following characteristics are common to organ-
specific and organ-nonspecific disorders except:
a. Autoantibody tests are of diagnostic value.
b. Antibodies may appear in each of the main immuno-
globulin classes.
c. Antigens are available to lymphoid system in low
concentrations.
d. Circulatory autoantibodies react with normal body
constituents.
c. Antigens are available to lymphoid system in low
concentrations.
- Antibody expression in the development of autoimmu-
nity is regulated by all the following factors except:
a. Genetic predisposition
b. Increasing age
c. Environmental factors (e.g., ultraviolet [UV]
radiation)
d. Active infectious disease
d. Active infectious disease
- The mechanism responsible for autoimmune disorder is:
a. Circulating immune complexes
b. Antigen excess
c. Antibody excess
d. Antigen deficiency
a. Circulating immune complexes
- One of the mechanisms believed to induce self-tolerance is:
a. Induction of responsiveness in immunocompetent
cells
b. Elimination of clone programmed to react with
antigen
c. Decreased suppressor cell activity
d. Stimulation of clones of immunocompetent cells
b. Elimination of clone programmed to react with
antigen
5-8. Match the following (use an answer only once).
5. _______ Acetylcholine receptor–blocking antibodies
6. _______ Anticardiolipin antibody
7. _______ Anti-DNA antibodies
8. _______ Anti–glomerular basement membrane
antibodies
a. Helpful in monitoring Addison’s disease
b. Found in one third of patients with myasthenia
gravis
c. Useful in monitoring the activity and exacerbations
of SLE
d. Suggestive of Goodpasture’s disease
e. Present in SLE and associated with arterial and
venous thrombosis
- b
- e
- c
- d
9-12. Match the following:
9. _______ Antinuclear ribonucleoprotein
10. _______ Anti-Scl
11. _______ Anti-Sm
12. _______ Anti–smooth muscle
a. Antibody to basic nonhistone nuclear protein,
diagnostic of systemic sclerosis
b. Present in bullous pemphigoid
c. Presence of antibody confirms diagnosis of SLE
d. Seen in viral disorders
e. Characteristic of mixed connective tissue disease
- e
- a
- c
- d
13-15. Match the following:
13. _______ Anti SS-A
14. _______ Histone-reactive antinuclear antibody
15. _______ PM-I antibody
a. Detectable in patients with myasthenia gravis
b. Demonstrable in Sjögren’s syndrome—sicca complex
c. Highly suggestive of drug-induced lupus
erythematosus
d. Found in one third of patients with uncomplicated
polymyositis and some patients with
dermatomyositis
e. Found in most patients with polymyositis
- b
- c
- e
- The term autoimmune disorder is used when:
a. Demonstrable immunoglobulins display specificity
for self antigens.
b. Cytotoxic T cells display specificity for self antigens.
c. Cytotoxic T cells contribute to the pathogenesis of
the disease.
d. All of the above
d. All of the above
17-21. Indicate true statements (A) and false statements
with (B).
17. _______ The presence of autoantibodies are only associ-
ated with autoimmune disease.
18. _______ In organ-specific disorders, antigens are only
available to the lymphoid system in low concentrations.
19. _______ There is a familial tendency to develop organ-
specific disorders.
20. _______ In organ-specific disorders, lesions are caused by
deposition of antigen-antibody complexes.
21. _______ In organ-specific disorders, there is a tendency
to develop cancer.
- b
- a
- a
- b
- a
- Self-recognition (tolerance) is induced by:
a. Burnet’s clonal selection theory
b. Elimination of the small clone of immunocompetent
cells programmed to react with the antigen
c. Induction of unresponsiveness in the immunocom-
petent cells through excessive antigen binding
d. All of the above
d. All of the above
23-26. Match each term with the correct description.
23. _______ Acetylcholine receptor binding antibody (AChR)
24. _______ Anticentromere antibody
25. _______ Antiintrinsic factor antibody
26. _______ Antimitochondrial antibody
a. Strongly suggestive, in a high titer, of primary biliary
binding antibody cirrhosis
b. Useful in the diagnosis of myasthenia gravis
c. Demonstrated in most patients with CREST
syndrome
d. Found in 60% of patients with pernicious anemia
- b
- c
- d
- a
- _______ Antimyelin antibody
- _______ Antimyocardial antibody
- _______ Cytoplasmic antineutrophil cytoplasmic
antibody (c-ANCA) - _______ Antinuclear antibody (ANA)
a. Associated with multiple myeloma
b. Marker for Wegener’s granulomatosis
c. Characteristic of untreated systemic lupus
erythematosus
d. Diagnostic of Dressler’s syndrome or rheumatic fever
- a
- d
- b
- c
31-34. Match each organ with the appropriate disease.
31. Thyroid____
a. Takayasu arteritis
b. Behcet’s disease
c. Grave’s disease
d. Scleroderma
c. Grave’s disease
Match each organ with the appropriate disease.
32. Stomach_____
a. Eosinophilia myalgia
b. Hashimoto’s disease
c. Raynaud’s phenomenon
d. Pernicious Anemia
d. Pernicious Anemia
Match each organ with the appropriate disease.
33. Pancreas____
a. Addison’s disease
b. Sheehan’s Syndrome
c. Insulin-dependent diabetes
d. Sjogren’s syndrome
c. Insulin-dependent diabetes
