Rheumatoid Arthritis Flashcards
what genes are associated w. RA
HLA-DRB1
PTPNN22
RA involves more efficient __ cells
that produce __
T cells
autoantibodies
3 rf for RA
female
smoker
25-55 yo
RA pathophys involves the formation of a __
which invades and destroys __
panus
bone and cartilage
what happens in the preclinical stage of RA
breakdown of tolerance
3 possible triggers for RA
bacterial antigens
viral antigens
smoking
RA involves proliferation of
synovium
RA usually has __ onset
with morning stiffness lasting >__
especially after __
insidious (chronic)
30 minutes
prolonged activity
RA involves __ swelling of joints
symmetric
RA is __articular
poly
joints mc affected by RA
lots of little joints:
PIP
MCP
wrists
ankles
MTP
RA gets __ w. activity
and OA gets __ w. activity
worse
better
hand manifestations of RA (3)
ulnar deviation of MCP joints
swan neck deformity
boutonniere deformity
hyperextension of PIP
flexion of DIP
swan neck deformity
flexion of PIP
extension of DIP
boutonniere deformity
extraarticular sx of RA (5)
fatigue, wt loss, low grade fever
rheumatoid nodules
vasculitis
what is this showing
rheumatoid nodules
what do you think when you see rheumatoid nodules
pt is almost surely RF (+)
where are RA nodules commonly found (3)
forearm extensors
over joints
pressure points
+/- lungs, sclerae, other tissues
describe RA nodules (2)
firm
not tender
what is this showing
RA vasculitis
ocular manifestations of RA
keratoconjunctivitis sicca
scleritis/episcleritis
scleromalacia
what do you think when you see RA and keratoconjunctivitis sicca, +/- xerostomia
secondary Sjorgen’s
mc pulmonary manifestation of RA
pleuritis
besides pleuritis, 3 other pulmonary manifestations of RA
pleural effusions
rheumatoid nodules
interstitial lung dz
cardiac manifestations of RA (3)
chronic inflammation → increased risk for CV dz
pericardial effusions
pericarditis
what does SANTA make you think of
RA → Felty syndrome
what does SANTA stand for
splenomegaly
anemia
neutropenia
thrombocytopenia
arthritis (RA)
in FELTY syndrome, neutropenia could be __
or the pt could have __
asymptomatic
frequent bacterial infxns
RA in FELTY syndrome is typically (3)
seropositive
erosive
severe
what % of RA pt’s are seronegative
15%
most specific bloodwork for RA
anti-CCP abs