Poststreptococcal Glomerulonephritis Flashcards
what type of strep causes psgn
GABS
where is psgn mc
developing countries
rf for psgn
4-15 yo
elderly
male
mc cause of acute nephritis worlwide
psgn
psgn develops __ weeks after an impetigo infxn
3-6
psgn develops __ weeks after a pharyngitis infxn
1-3
__ can be the only symptom of psgn
or the pt can have full __
microscopic hematuria
nephritic syndrome
symptoms of nephritic syndrome (5)
red/brown urine
proteinuria
edema
htn
elevated serum creatinine
mc presenting symptoms of nephritic syndrome
generalized edema
gross hematuria
htn
systemic sx of psgn (4)
ha
malaise
anorexia
flankl pain
what will UA for psgn show (3)
RBCs
red cell clasts
proteinuria
elevated renal values in psgn
BUN
Cr
in psgn, serum complement will be __
bc __
low
acute immune rxn
in psgn, what 3 serology tests are indicative of recent strep infxn
ASO (anti streptolysin O)
anti-DNAse
streptozyme
what do you think when you see “honey colored crust” type rash around the mouth
strep impetigo infxn
severe symptom of psgn
pulmonary htn
why would we do strep serology over culture
w. normal swab test, it is unlikely that pt will still be positive for strep
when does complement return to normal
6-8 weeks
dx for psgn (2)
clinical findings
proof of recent GAS infxn
what diagnostic test is not commonly performed for psgn
renal bx
when would you perform renal bx for psgn
concern for:
lupus nephritis
IgA nephropathy
or other intrinsic renal issue
goals of psgn tx
eradicate residual nephritogenic bacteria
supportive care
there is no specific therapy for psgn, but __ especially needs to be taken care of
volume overload
abx for psgn
penicillin
- only drug shown to reduce rates of acute rheumatic fever*
- alternate first line: Amoxicillin*
tx for psgn for mildly penicillin allergic pt
cephalexin (Keflex)
abx for pt w. severe penicillin allergy
azithromycin
why do some not recommend abx for psgn
they don’t alter the course of the disease
strep infxn already came and went
abx for psgn might help to prevent
person to person spread
most pt’s recover completely from psgn; 3 long term complications for pt’s who do not (3)
HTN
recurrent proteinuria
renal insufficiency
when does Cr normalize in psgn
3-4 weeks
pt usually diureses w.in __ of psgn infxn
1 week
hematuria usually resolves in __ of psgn infxn
3-6 months
which sx resolves the slowest in psgn
proteinuria
rheumatic fever results from an __ rxn to GAS infxn
autoimmune
mc cause of heart disease in kids in developing countries
rheumatic fever
mc pt population w. rheumatic fever
5-14 yo
usual onset of rheumatic fever post GAS infxn
10 days
mc presentation pattern in rheumatic fever (2)
acute febrile illness → joint manifestations and/or carditis
neurologic/behavioral manifestations → chorea
symptoms of rheumatic fever
JONES:
joint pain
o (heart) - carditis
nodular sq lesions
erythema/rash
sydenhams chorea
what sx is seen in 90% of pt w. rheumatic fever
fever
duh!
signs of carditis in rheumatic fever (4)
dyspena
orthopnea
cp
palpitations
describe the joint pain associated w. rheumatic fever (2)
large joints
migratory
joint pain associated w. rheumatic fever has a dramatic response to
nsaids/salicylates
describe syndenham’s chorea (4)
uncontrolled jerky movements
limbs, face, tongue
usually worse on one side
stop wile sleeping
describe the nodular lesions associated w. rheumatic fever
painless
resolve in 1-2 weeks
the rash associated w. rheumatic fever is called
erythema marginatum
you can’t use jones criteria without
evidence of strep infxn
in jones criteria, you need __ major
OR
__ major plus
__ minor
2 major
OR
1 major PLUS 2 minor
major jones criteria (5)
joints → arthritis
carditis and valvulitis
subcutaneous nodules
erythema marginatum
CNS → usually Sydenham’s
minor jones criteria (4)
arthralgia
fever
apr
prolonged PR on ekg
4 main cardiac/ekg findings of rheumatoid fever
pr prolongation → AV block
pancarditis
mitral valve regurgitation
S3
valve mc affected by rheumatic fever
mitral
tx for acute rheumatic fever
abx
NSAIDs → for arthritis
manage carditis
nsaid mc used for rheumatoid fever arthritis
aspirin
also naproxen
NSAIDs for rheumatoid fever arthritis should be taken until
all joint sx have resolved
prophylactic abx for rheumatic fever
penicilin or clindamycin
abs directed hypersensitivity rxn against antigen on cells or extracellular materials (ex basement membrane)
type II
Ab-Ag complexes activate complement via classic pathway, causing cell lysis or extracellular tissue damage
type II hypersensitivity run
Ab Ag complexes promote tissue damage thru complement activation - alternate pathway
type III hypersensitivity run
Ab Ag complexes deposited in tissues
type III hypersensitivity run
acute rheumatic fever is a __ hypersensitivity rxn
post streptococcal glomerulonephritis is a __ hypersensitivity rxn
acute rheumatic fever: II
psgn: III