Rheumatoid Arthritis Flashcards

1
Q

When activated by macrophage-induced cytokines, what impact do T cells have

A
  • synovial cells proliferate

- bone breakdown

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2
Q

When activated by cytokines, B cells release what 2 Abs

A
  • RF

- anti-CCP

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3
Q

Most common type of RF

A

IgM

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4
Q

RF targets what Fc portion of the body’s own antibodies

A

IgG

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5
Q

Why is anti-CPP preferred to RF

A
  • > sensitive

- >common

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6
Q

Common epi for RA

A
  • x3 F

- middle age

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7
Q

Common gene in RA

A

HLADR4

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8
Q

Less common gene in RA

A

HLADR1

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9
Q

Limited short episodes of inflammatory arthritis that lasts 1-2 days

A

Palindromic arthritis

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10
Q

Joints that are almost never affected by RA

A

DIPJs

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11
Q

Baker’s cysts in RA are found

A

Behind knees

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12
Q

Atlantoaxial subluxation can lead to further complication of

A

SC compression

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13
Q

What letter shape is made at the thumb

A

Z

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14
Q

Hyperextended PIP + flexed DIP

A

Swan neck deformity

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15
Q

Hyperextended DIP + flexed PIP

A

Boutonnières deformity (unopposed flexion due to central slip in extensor compartments)

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16
Q

Ulnar deviation happens in what joints

A

MCPJs

17
Q

Palpating synovial is characterised by

A

‘Boggy’ inflammatory swelling

18
Q

Minimum score required to diagnose RA

A

6

19
Q

DAS28 score is used to

A

Monitor disease activity

20
Q

Factors worsening prognosis (think age, gender, etc)

A
  • young onset
  • male
  • ++ joints & organs affected
  • RF + anti CCP present
  • visible erosions
21
Q

Meds used to induce remission

A

NSAIDs/COX-2 inhibitors

22
Q

1st line meds for DMARDs (only one needed at this step)

A
  • methotrexate
  • lefluomide
  • sulfasalazine
  • hydroxychloroquine (mildest)
23
Q

2nd line meds

A

2 of 1st line options

24
Q

3rd line meds

A

Methotrexate + biological agent (TNFi)

25
Q

4th line meds

A

Methotrexate + rituximab

26
Q

Meds to consider in preggo

A
  • sulfasalazine

- hydrochloroquine

27
Q

Common SEs to biological agents

A
  • immunosuppression —> prone to infection (TB/HepB reactivation)
  • neuropathy
  • BM suppression
28
Q

Name 3 TNFi

A
  • adalimumab (mono anti)
  • infliximab (mono anti)
  • etancercept
29
Q

Name anti-CD20 biological agent

A

Rituximab (mono anti)

30
Q

Pulm fibrosis is common SE of

A

Methotrexate

31
Q

Hptn and p oedema are common SEs of

A

Leflunomide

32
Q

Male infertility (— sperm count) is common SE of

A

Sulfasalazine

33
Q

Nightmare and reduced visual activity are common SEs of

A

Hydroxychloroquine

34
Q

Night sweats and thrombocytopenia are common SEs of

A

Rituximab

35
Q

what is caplan’s syndrome (extra-articular manifestation)

A

pulmonary fibrosis w/ pulmonary nodules

36
Q

inflammation that causes small airway obstruction (extra-articular manifestation)

A

bronchiolitis obliterans

37
Q

felty’s syndrome

A
  • RA
  • neutropenia
  • splenomegaly
38
Q

extra-articular autoimmune condition that affects secreting ducts

A

Sjogren’s syndrome

39
Q

Med used in RA that can induce retinopathy

A

Hydroxychloroquine