Rheumatic Fever Flashcards
Cause of Rheumatic Fever
Pharyngeal Infection with group A Beta-hemolytic Streptococci
Late Complications Include
- Rheumatic Heart Disease which affects high pressure valves (Mitral > Aortic»_space; Tricuspid)
Early and Late Lesions of Rheumatic Fever
- Mitral Valve Regur, followed by mitral stenosis.
Histology Associated with Rheumatic Fever
- Aschoff Bodies (granuloma w/giant cells)
- Anitschkow’s Cells (activated histiocytes)
Granuloma with Giant Cells that have wavy chromatin aggregation
Aschoff Bodies (also known as Caterpillar Cells
Activated Histiocytes
Anitschkow’s Cells
Evidence of Prior Group A Beta-Hemolytic Strep Include
- Elevated ASO Titers
- Anti-DNase B Titers
Symptoms Associated with Rheumatic Fever (FEVERSS)
FEVERSS
- Fever
- Erythema Marginatum
- Valvular Damage
- ESR (Increased)
- Red-hot Joints (Migratory polyarthritis)
- Subcutaneous Nodules
- St. Vitus’ Dance (Sydenham’s Chorea)
Subendothelial Collections of Aschoff Nodules, usually in the Left Atrium, that form plaques.
MacCallum Plaques
Commisural Fusion, Leaflet Thickening, and thickening/fusion of tendinous cords lead to
Fishmouth or Buttonhole Stenoses
Why are Rheumatic Fever Consequences not a DIRECT effect of bacteria?
- It is caused by molecular mimicry when the body creates antibodies against “M” protein.
Early Deaths are due to what?
Myocarditis
