Rheumatic Conditions - Lecture 6 Flashcards

1
Q

Musculoskeletal Red flags

A
Age of onset 55yr
Violent trauma
Constant progressive, non mechanical pain (no relief with bed rest)
Past medical history of malignant tumour
Prolonged use of corticosteroids
Drug abuse, immunosuppression, HIV
Systematically unwell
Unexplained weight loss
Widespread neurology (including cauda equina syndrome)
Structural deformity
Fever
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2
Q

Joint pain - red flags

A

Erythema, warmth, effusion, and decreased range of motion
Fever with acute joint pain
Acute joint pain in a sexually active young adult
Skin breaks with signs of cellulitis adjacent to the affected joint
Underlying bleeding disorder or use of anticoagulants
Systemic or extra-articular symptoms

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3
Q

5 common presenting complaints

A
pain - think of symmetry/asymmetry, local or generalised
stiffness
joint swelling
impaired function
constitutional symptoms
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4
Q

What joints are commonly involved in RA?

A

metacarpal-phalangeal (MCP)
proximal interphalangeal (PIP)
(symmetrically involved)

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5
Q

Asymmetrical involvement of the PIP & DIP are common with what three conditions

A

OA
gout
psoriatic arthritis

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6
Q

What is the main disease affecting the sacro-iliac joint?

A

ankylosing spondylitis

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7
Q

When chronic widespread pain has been present for more than 3 months what may it be?

3 conditions & one general

A

multiple joint probs or myopathy
fibromyalgia with many muscle tenderpoints
joint hypermobility syndrome
polymyalgia rheumatica - with pain in hips or shoulder girdles

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8
Q

Mechanical disorders are aggravated by?

A

tend to worsen with activity, though sometimes may get disturbed sleep
no night pain
no systemic signs
chronic symptoms

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9
Q

Inflammatory diseases - characteristics?

A

painful at rest & activity - associated stiffness (needs to last longer than an hour to be considered inflamm. ) can be relieved with movement
night time pain - also think cancer etc
systemic systems present - also think cancer etc
acute or sub acute presentation

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10
Q

Patterns of stiffness in Rheumatic disease, joint inflamm., OA, spondy…….

A

rheumatic disease - discomfort when moving after a rest period
joint inflamm. - stiffness is more severe & increases as inflamm. does
OA - theatre sign - short lived stiffness upin standing after hours of being still
spondylitis - stiffness in low back in morning lasting over an hour

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11
Q

Joint swelling - what does it indicate & what is happening (physiologically) in joint?

A

indicates - an inflamm. condition, infection or trauma

Due to - soft tissue inflamm, thickening of synovial membrane, excessive synovial fluid causing effusion

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12
Q

Septic arthritis will show by……..think pain & inflamm.

A

very rapid onset of swelling and pain

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13
Q

Constitutional symptoms - one of the five common presenting complaints relate to auto immune diseases - name some signs & what they might be from

A
dry eyes
skin - nodules or vasculitis
renal - glomerulonephritis
lung - fibrosing alveolitis
CDV - ischemia, thrombosis, pulmonary hypertension
neural - cerebral vasculitis
blood - lymphoma
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14
Q

Name 3 seronegative arthropathies and some signs

A

ankylosing spondylitis: eye - uveitits, lung - fibrosis, CDV - aortic valve disease
psoriatic arthritis - skin rashes, nail pitting/ridging
reactive arthritis - GU infection

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15
Q

Discuss diffuse idiopathic skeletal hyperostosis

A

ossification of ligaments that mainly affects the spine (longitudinal ligs)
motion is possible - z joints & SI spared, IVD too
more men than women affected & over 50 years often in conjunction with arthritis, bursitis, tendinitis

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16
Q

Fibromyalgia

MUST KNOW

A

Epi - Women 7:1, young to middle aged. often accompanies an autoimmune or systemic rheumatic disorder, 65% of people with Lupus
Aet - Centrally mediated disorder of pain sensitivity, precipitated by viral/systemic infection or trauma, stress
Patho - allodynia, similar to central sensitisation
Signs/symptoms - widespread pain, poor sleep, concentration, memory, difficult to diagnose, 3 months to years

17
Q

Polymyalgia Rheumatica

MUST KNOW

A

Epi - 50plus, Men/Women: 2:1 - 40-60% of patients will have temporal (giant cell) arteritis
Note - look for a new type of HA, jaw pain with chewing,unexplained sub-acute fever, pain over temporalis
Aet/Path - unknown, inflamm.
Signs/Symptoms - sudden aches & pains, often bilateral hips & shoulders, neck, back, thigh, malaise, low fever, morning stiffness, weight loss.

18
Q

Ankylosing spondylitis

MUST KNOW

A

Epi - Men:3:1, 15-45 years, 0.2% pop
Aet - unknown
Path - SI most affected joint & spine, immune mediated inflamm. where tend/ligs insert into bone leading to degradation & ossification of the spine, bamboo spine
Signs/symptoms - back pain, bilateral inflamm of SI, night pain, morning back stiffness for over an hour, pain in tendons/ligs, maybe chest too, accentuated kyphosis, decreased ROM…

19
Q

Psoriasis/Psoriatic Arthritis

MUST KNOW

A

Epi - 2% of pop, late teens & 50s, men & women, girls more than boys, 30% will develop psoriatic arthritis
Aet - genetic, envirinmental, infections
Patho - inflamm. of dermis & epidermis, proliferation of keratinocytes
Symp/signs - red scaly skin, often symmetrical, elbows, knees, scalp, lower back
Psoriatic arthritis - PIJ & DIJ morning stiffness for over an hour

20
Q

Rheumatoid arthritis

MUST KNOW

A

Epi - Female/Male: 3:1, 35-50 years, 1% of pop
Aet - unknown - environmental/genetics…
Patho - onset slow, immune system targets lining of joints, causing inflamm. & joint damage. Thickens synovial membrane, degrade cartilage. Usually affects smaller joints, such as the joints in the hands and feet, can effect larger, nodules can devel. in organs (30%)
Signs/Symp - symmet. inflamm. of hands (index/middle) & feet, joint pain, tenderness, morning stiffness over an hour, night pain, better with activity, worse at rest, fatigue, malaise