Rheum antibodies

Question 1

Antinuclear factor (ANF)

Answer 1

SLE
Systemic sclerosis
Sjorgens syndrome

Question 2

Anti SS DNA

Answer 2

SLE

Question 3

Anti DS DNA

Answer 3

SLE + shows disease activity

Question 4

Anti-histone

Answer 4

SLE and especially drug induced SLE

Question 5

Causes of drug induced SLE

Answer 5

Procainamide
Hydralazine
Isoniazid
Minocycline
Phenytoin

Question 6

Anti-Sm

Answer 6

SLE (specific but insensitive)

Question 7

Anti-RNP

Answer 7

Mixed connective tissue disorder
SLE

Question 8

Anti-Ro

Answer 8

Primary Sjorgens
SLE

Question 9

Anti-La

Answer 9

Primary Sjorgens
SLE

Question 10

Anti-centromere

Answer 10

Systemic sclerosis
Scleroderma

Question 11

Anti-nucleolar RNA

Answer 11

Systemic sclerosis

Question 12

Anti-Scl70

Answer 12

Diffuse cutaneous systemic sclerosis

Question 13

Anti-PM/Scl

Answer 13

Polymyositis
Systemic sclerosis overlap syndrome

Question 14

Anti-Jo

Answer 14

Dermatomyositis

Question 15

Anti-ribosomal-P

Answer 15

SLE

Question 16

Rheumatoid factor

Answer 16

RhA
Sjorgens syndrome
2-10% of healthy adults

Question 17

Anti-CCP

Answer 17

Rheumatoid arthritis

Question 18

Anti-phospholipid abs

Answer 18

Primary antiphospholipid sydrome
SLE

Question 19

ANCA

Answer 19

Vasculitis:
Granulomatosis with polyangiitis
Microscopic polyangiitis
Eosinophilic granulomatosis with polyangiitis