Rheum

Question 1

Osteoarthritis

Answer 1

Capsaicin (topical analgesia - TRPV1 agonist)
Oral paracetamol
topical NSAID

Question 2

Rheumatoid Arthritis

Answer 2

1) DMARD - hydroxychloroquine - blocks toll like receptors on antigen presenting cells
2) Prednisolone
3) NSAID

Question 3

Gout

Answer 3

`In flare: NSAID w/ PPI
(Ibuprofen + omeprazole)
or Colchicine
or prednisolone

General: Low purine, low weight, avoid alcohol
1) Allopurinol - xanthan oxidase inhibitor

Question 4

Reactive arthritis

Answer 4

NSAID, antibiotics, steroid injections.

DMARD (methotrexate) if recurrent. Anti TNF can be used

Question 5

Psoriatic arthritis

Answer 5

Mild - NSAID
Severe - DMARD (methotrexate or sulfasalazine)
Anti TNF (infliximab - TNF alpha inhibitor)

Question 6

Ankylosing spondylitis

Answer 6

1) NSAID
2) Steroids
3) Anti-TNF - Infliximab

Question 7

Pseudogout

Answer 7

Colchicine
Corticosteroid
Aspiration of joints

in chronic
DMARD - methotrexate/hydroxychloroquine

Question 8

Osteoporosis

Answer 8

Bisphosphonates - interfere with osteoclasts, reducing their activity (alendronic acid)

Question 9

Septic arthritis

Answer 9

IV antibiotics

Flucloxacillin is first line

Question 10

Osteomyelitis

Answer 10

Ceftriaxone

Question 11

SLE

Answer 11

Prednisolone, Hydroxychloroquine, NSAIDs

Question 12

Antiphospholipid syndrome

Answer 12

Aspirin and SC heparin