Rheum #1 Flashcards
What is arthralgia
Perception of jt pain without obvious clinical findings
–May be referred pain from mm, tendon or bone
What is HLA B27 associated w/ (4)
As
Reactive arthritis
Enteropathic arthritis
Psoriatic arthritis
What is HLA DR4, DR1 associated w
Rheumatic arthritis
What is HLA DR3 associated w
Sjogren syndrome
Systemic lupus erthematosus
What are the seropositive inflammatory arthritis (5)
RA SLE scleroderma DMM/PM Sjorgens syndrome
What are the signs of inflammatory arthritis
- Pain at rest + relieved by gentle motion
- morning stiffness >1hr
- Warmth/swelling etc
What is the use of jt aspirations
Red swollen and painful its.
main differentials include gout, psuedogout and septic arthritis
Autoantibodies in Ra
Rheumatoid factor + Anti CCP
What are the 3 autoantibodies for SLE
Anti ds DNA
Anti Sm
Antibodies against RBCs, WBCs or platlets
What are the antibodies agains Sjorgens syndrome
Anti Ro
Anti LA
What is the antibody against drug induced SLE
Anti histone
What is the antibody against CREST
anti centromere
What is the antibody against PM/DMM
anti Jo1 (both) Anti Mi 2 (DMM)
What condition is related to positive C-ANCA (antineuotrophil cytoplasmic antibody)
granulomatosis with polyangitis (GPA) (Wegener’s Granulomatosis)
What disease associated with positive p-ANCA
Churg-Strauss Syndrome
part of hands unaffected in Rheumatoid Arthritis
DIPs and 1st carpal meta carpal
What are the jt deformities seen in RA
Boutonnieres
Swan Neck
Ulnar deviation of fingers
Sjogrens Syndrome definition
keratoconjunctivitis sicca + Xerostomia (dry eyes and mouth)
Caplan’s Syndrome def
RA + Pneumoconiosis (manifests as multiple intrapulmonary nodules
Very dangerous aspect of C-spine and Rheum Arthritis
Atlanto-axial (c1 and c2) subluxation (impingement, and damage to spinal cord)
Felty’s Syndrome def
arthritis + Splenomegaly + Neutropenia
what chart should i use for RA diagnosis and score needed
2010 ACR/EULAR criteira (6/10 is a definite score for RA)
best initial test for RA
X ray
Tx for RA
- early diagnosis and early intervention with DMARDs and biologics–> Methotrexate is gold standard
Exercise
gold standard drug for RA
methotrexate
What type of anemia would you expect to see with RA?
Low hemoglobin, then check MCV (mean corpuscle volume), concerned if MCV <80 for
microcytic hyperchromic anemia!
