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CD 3305 > Rheum #1 > Flashcards

Rheum #1 Flashcards

1
Q

What is arthralgia

A

Perception of jt pain without obvious clinical findings

–May be referred pain from mm, tendon or bone

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2
Q

What is HLA B27 associated w/ (4)

A

As
Reactive arthritis
Enteropathic arthritis
Psoriatic arthritis

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3
Q

What is HLA DR4, DR1 associated w

A

Rheumatic arthritis

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4
Q

What is HLA DR3 associated w

A

Sjogren syndrome

Systemic lupus erthematosus

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5
Q

What are the seropositive inflammatory arthritis (5)

A 
RA
SLE
scleroderma
DMM/PM
Sjorgens syndrome
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6
Q

What are the signs of inflammatory arthritis

A
  • Pain at rest + relieved by gentle motion
  • morning stiffness >1hr
  • Warmth/swelling etc
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7
Q

What is the use of jt aspirations

A

Red swollen and painful its.

main differentials include gout, psuedogout and septic arthritis

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8
Q

Autoantibodies in Ra

A

Rheumatoid factor + Anti CCP

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9
Q

What are the 3 autoantibodies for SLE

A

Anti ds DNA
Anti Sm
Antibodies against RBCs, WBCs or platlets

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10
Q

What are the antibodies agains Sjorgens syndrome

A

Anti Ro

Anti LA

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11
Q

What is the antibody against drug induced SLE

A

Anti histone

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12
Q

What is the antibody against CREST

A

anti centromere

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13
Q

What is the antibody against PM/DMM

A 
anti Jo1 (both)
Anti Mi 2 (DMM)
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14
Q

What condition is related to positive C-ANCA (antineuotrophil cytoplasmic antibody)

A

granulomatosis with polyangitis (GPA) (Wegener’s Granulomatosis)

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15
Q

What disease associated with positive p-ANCA

A

Churg-Strauss Syndrome

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16
Q

part of hands unaffected in Rheumatoid Arthritis

A

DIPs and 1st carpal meta carpal

17
Q

What are the jt deformities seen in RA

A

Boutonnieres
Swan Neck
Ulnar deviation of fingers

18
Q

Sjogrens Syndrome definition

A

keratoconjunctivitis sicca + Xerostomia (dry eyes and mouth)

19
Q

Caplan’s Syndrome def

A

RA + Pneumoconiosis (manifests as multiple intrapulmonary nodules

20
Q

Very dangerous aspect of C-spine and Rheum Arthritis

A

Atlanto-axial (c1 and c2) subluxation (impingement, and damage to spinal cord)

21
Q

Felty’s Syndrome def

A

arthritis + Splenomegaly + Neutropenia

22
Q

what chart should i use for RA diagnosis and score needed

A

2010 ACR/EULAR criteira (6/10 is a definite score for RA)

23
Q

best initial test for RA

A

X ray

24
Q

Tx for RA

A
  • early diagnosis and early intervention with DMARDs and biologics–> Methotrexate is gold standard

Exercise

25
Q

gold standard drug for RA

A

methotrexate

26
Q

What type of anemia would you expect to see with RA?

A

Low hemoglobin, then check MCV (mean corpuscle volume), concerned if MCV <80 for

microcytic hyperchromic anemia!

CD 3305 (15 decks)

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