RH incompatibilty

Question 1

Risk Factors

Answer 1

*Delivery: Alloimmunization most commonly occurs when fetal RBCs enter the mother’s circulation transplacentally at delivery.
*Abortion
Wrong blood transfusion.
*amniocentesis, CVS, ectopic pregnancy, D&C, abruptio placentae, and placenta previa.
*Any vaginal bleeding

Question 2

Complications:

Answer 2

Hemolytic disease of the newborn (HDN)
**hydrops fetalis

Question 3

Managment

Answer 3

**If the atypical antibody titer is ≤1:8:
-management is conservative
Repeat the titer monthly as long as it remains ≤1:8.

**If antibodies titer >1:8 Doppler MCA ultrasound is the procedure of choice (to check fetal anemia)
-In case of severe anemia go with intra-uterine blood transfusion.
age ≥34 weeks?, perform delivery.

Question 4

prevention

Answer 4

RhoGAM is pooled anti-D IgG passive antibodies