APLA syndrome

Question 1

what is APLA?

Answer 1

an autoimmune disease associated with increased risk ofthrombosis

Question 2

key word for APLA question

Answer 2

recurrent early pregnancy loss.

Question 3

APLA clinical features

Answer 3

*venous or arterial thromboembolic disease (DVT,PE,ischemic stroke,transient attack)

• adverse pregnancy outcome
  -unexplained embryonic or fetal loss
  -premature birth due to placental insufficiency

Question 4

APLA laboratory findings

Answer 4

*lupus anticoagulant effect
*presence of specific antiphospholipid antibodies
-anticardiolipin antobody
-anti-beta2-glycoprotein-1 antibody

Question 5

APLA associated with ?

Answer 5

RA and SLE