NIPT and NTD

Question 1

indication for NIPT

Answer 1

*maternal age >35 (always do NIPT)(increased risk for down and trisomies)
*abnormal maternal serum screening test
*sonographic findings associated with fetal aneuploidy
*previous pregnancy with fetal aneuploidy
*parental-balanced robertsonian translocation

Question 2

NIPT application

Answer 2

*screening for trisomy 21,18,13 ,sex-chromosome aneuploidies
*fetal sex determination

Question 3

NTD ?

Answer 3

*occur when the neural tube does not close properly.
*folic acid supplementation helps reduce the risk of developing neural tube defects

Question 4

folic acid dosage

Answer 4

if previous NTD -4mg daily
if no previous..-0.4 mg daily

Question 5

what is the chance of having another child with NTD

Answer 5

*2-5%.
*After having 2 children with NTDs, the risk of having another child with the defect increases to up to 10%

Question 6

NIPT

Answer 6

non invasive pregnancy test