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BB LECT (midterm) > Rh deficiency > Flashcards

Rh deficiency Flashcards

1
Q

fail to express any Rh antigens on the RBC surface

A

Rhnull syndrome

“ –/–”

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2
Q

Rhnull syndrome can be __ or __

A

amorphic type or regulator type

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3
Q

Rhnull syndrome was first describe in 1961 from?

A

an aboriginal Australian woman

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4
Q

Rhnull individuals are negative for what angtigen/s?

A

LW and FY5

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5
Q

antigen in the duffy blood group

A

FY5

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6
Q

Rhnull deficiency with reduced expression of?

A

CD4 and glycophorin B

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7
Q

carries S, s, and U antigens

A

glycophorin B

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8
Q

Rhnull patients produces what antibody?

A

IgG

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9
Q

IgG of Rhnull patients was also known as

A

anti-Rh29 against Rh antigens

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10
Q

t or f: Only Rhnull person can donate blood to an Rhnull person

A

true

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11
Q

in this type of syndrome, mutation occurs in the RHAG gene which results in no RHAG protein expression

A

regulator

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12
Q

which Rhnull syndrome is more common?

A

regulator type

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13
Q

regulator type don’t have these kinds of protein on RBC membrane, enumerate!

A

RhD or RhCE

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14
Q

identify the type of Rhnull

Individuals have a normal RHD and RHCE genes

A

regulator

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15
Q

there is a nonsense mutation in RHCE genes inherited from each parent and a common
deletion of the RHD gene.

A

amorphic type

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16
Q

this gene is normal in amorphic type

A

RHAG gene

17
Q

Individuals with Rhnull syndrome demonstrates __

enumerate the 9

A
  • Mild compensated hemolytic anemia
  • Reticulocytosis
  • Stomatocytosis
  • Decrease in hemoglobin and hematocrit
  • Increase in hemoglobin F,
  • Decrease in serum haptoglobin
  • Abnormalities in CO2 permeability
  • Phospholipid asymmetry
  • Increases osmotic fragility
18
Q

this deficiency has with partial suppression of RH gene expression caused by missense mutations in the RHAG

A

Rhmod

19
Q

enumerate what is altered in the Rhmod?

A
  • RhAG protein
  • Rh antigens
20
Q

RBCs exhibit other blood group antigens (S, s and U antigens may be depressed)

A

Rhmod

21
Q

differentiate Rhnull and Rhmod

A

they are similar but Rh null but Rhmod clinical symptoms are less severe

BB LECT (midterm) (6 decks)

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