Rh deficiency Flashcards
fail to express any Rh antigens on the RBC surface
Rhnull syndrome
“ –/–”
Rhnull syndrome can be __ or __
amorphic type or regulator type
Rhnull syndrome was first describe in 1961 from?
an aboriginal Australian woman
Rhnull individuals are negative for what angtigen/s?
LW and FY5
antigen in the duffy blood group
FY5
Rhnull deficiency with reduced expression of?
CD4 and glycophorin B
carries S, s, and U antigens
glycophorin B
Rhnull patients produces what antibody?
IgG
IgG of Rhnull patients was also known as
anti-Rh29 against Rh antigens
t or f: Only Rhnull person can donate blood to an Rhnull person
true
in this type of syndrome, mutation occurs in the RHAG gene which results in no RHAG protein expression
regulator
which Rhnull syndrome is more common?
regulator type
regulator type don’t have these kinds of protein on RBC membrane, enumerate!
RhD or RhCE
identify the type of Rhnull
Individuals have a normal RHD and RHCE genes
regulator
there is a nonsense mutation in RHCE genes inherited from each parent and a common
deletion of the RHD gene.
amorphic type
this gene is normal in amorphic type
RHAG gene
Individuals with Rhnull syndrome demonstrates __
enumerate the 9
- Mild compensated hemolytic anemia
- Reticulocytosis
- Stomatocytosis
- Decrease in hemoglobin and hematocrit
- Increase in hemoglobin F,
- Decrease in serum haptoglobin
- Abnormalities in CO2 permeability
- Phospholipid asymmetry
- Increases osmotic fragility
this deficiency has with partial suppression of RH gene expression caused by missense mutations in the RHAG
Rhmod
enumerate what is altered in the Rhmod?
- RhAG protein
- Rh antigens
RBCs exhibit other blood group antigens (S, s and U antigens may be depressed)
Rhmod
differentiate Rhnull and Rhmod
they are similar but Rh null but Rhmod clinical symptoms are less severe
