Rh Blood Group Flashcards
What did Fisher-Race theory propose?
Three distinct genes
What did Wiener propose?
One gene was responsible for Rh
What are the five major Rh antigens?
D, C, c, E, e
What is the frequency of the D gene in caucasians?
85%
What is the most common haplotypes for white, black, native amer., and asian?
DCe - W: 42, NA: 44, A: 70
Dce - B: 44
What is a six number digit adopted for blood group specificity?
ISBT (International Society of Blood Transfusions)
Which chromosome is Rh located on?
Chromosome 1
What is responsible for the expression of Rh?
RHD
RHCE
RHAG (Rh Associated Glycoprotein)
Which chromosome is RHAG located on?
Chromosome 6
Coexpressor
How do patients get negative Rh based on ethnicity?
Deletion or alteration of RHD
Two RHCE genes
What are the genetic mechanisms that weak D can arise from?
Genetic Weak
Position Effect (C/Trans)
Partial D
Del
What does Partial D do when exposed to D positive RBCs?
Produce anti D to the epitopes
What do we administer to Rh negative mothers?
Rh Immune Globulin (RhIG)
What type of testing has the optimal detection at 37 C/LISS phase?
Indirect Antiglobulin Testing (IATs)
When does antibody appear in the body after primary and secondary exposure?
Primary: 120 days
Secondary: 2-7 days (Anamnestic)
What is the regulator type of Rh null?
RHAG gene is absent or mutated
What is the amorph type of Rh null?
RHCE Mutation
RHD Deletion
What morphology do we see in Rh null and Amorph null?
Reticulocytes
Stomatocytes
Increase in Hemoglobin F
What is Rh null syndrome?
Lack of all Rh antigens on RBCs
What is Rh mod?
RHAG Mutations
