RGCs and Amacrines (M2) Flashcards
What type of neurotransmitter does AI amacrine cells release? 1. What are these cells involved in? 2
- GABA
2. lateral inhibition
What are the visual symptoms that a patient with multiple sclerosis can present with?
- dec VA
- reduction in visual fields
- sudden-onset diplopia
- pupillary defects
- color vision defects
- Uhthoff’s sign
- Pulfrich’s stereo phenomenon
Where do starburst amacrines with cell bodies in the GCL stratify in?
ON sublamina
Is the synapse from AII amacrine cells onto ON cone bipolar cells sign-conserving or -inverting? 1. What is the connection like? 2
- conserving
2. gap junctions
How many different types of amacrine cells are there?
20-40
What is the process of action potentials jumping node to node to increase speed called?
saltatory propagation
How many midget bipolar cells are connected to a foveal midget RGC? 1. What does this setup gear the vision towards? 2
- one
2. high spatial resolution
Where are the voltage-gated sodium channels located that lead to saltatory propagation?
Nodes of Ranvier
For midget RGCs what is the relative cell body size? 1. Dendrites branching? 2. Stratification type? 3. Percent of total RGCs? 4
- medium
- small
- ON or OFF sublamina of IPL
- 75-80%
Do midget or parsol RGCs exhibit center-surround antagonism?
both
What is the ratio of amacrine:bipolar synapses for parasol RGCs? 1. Midget RGCs? 2
- 70:30
2. 50:50
What do AI amacrine cells have roles in?
- amplifying rod-mediated signals
2. mediating the receptive field surround in RGCs during scotopic conditions (light more apparent)
What is the dendritic spread amount for small amacrine cells? 1. Medium? 2. Wide-field? 3
- less than 300 um
- between 300 and 500 um
- greater than 500 um
What percentage of the foveal RGCs are midget? 1. Periphery RGCs? 2
- 95%
2. 45%
For parasol RGCs what is the relative cell body size? 1. Dendrites branching? 2. Stratification type? 3. Percent of total RGCs? 4
- large
- large
- ON or OFF sublamina of IPL
- 5-10%
Do amacrine cells have graded potentials or action potentials?
action potentials
Do midget or parasol RGCs have a more sustained response to light onset or offset? 1. Which have more transient response? 2
- midget RGC
2. parasol RGC