Disorders of the Ascending Pathway (M2) Flashcards

1
Q

What are the signs and symptoms of strabismic amblyopia?

A
  1. eye turn of affected eye
  2. reduced optotype (Snellen) acuity in affected eye
  3. suppression of affected eye during binocular viewing
  4. little or no stereopsis
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2
Q

At what age is there a lifetime maximum of synapses in V1?

A

0.5-1yr

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3
Q

Which portion of the visual system is still developing postnatally? 1. Which is done? 2

A
  1. V1 still developing

2. LGN fully retinotopically wired

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4
Q

Is refractive amblyopia congenital or developmental?

A

developmental

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5
Q

What is the process of how strabismic amblyopia develops from before and after birth?

A
  1. prenatal waves from retina to LGN are ok
  2. postnatally, the eye turn makes the same stimulus fall on non-corresponding positions of the two retinas
  3. postnatal waves do not encourage orderly, projections
  4. suppression of the turned eye occurs to prevent diplopia
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6
Q

What are the patients that have spatial-frequency-tuned channels and then lose them? 1. Why does this occur? 2

A
  1. refractive amblyopes
  2. more blur of proximal stimulus during critical period = more high spatial frequency loss (modulation transfer function)
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7
Q

What are the clinical consequences of strabismic amblyopia at the primary visual cortex?

A

1, impaired visual pattern recognition (reduced optotype acuity)

  1. crowding (reduce optotype)
  2. poor Vernier acuity
  3. poor grating orientation identification acuity (“grating vertical or horizontal?”)
  4. near-normal grating resolution acuity (Teller acuity)
  5. poor stereo acuity
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8
Q

What happens to the cells of the “handicapped” eye in the primary visual cortex if there is an amblyopia?

A

lose synaptic connections, making narrower columns

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9
Q

Why does refractive amblyopia tend to occur in cases of anisometropia?

A

accommodation is consensual and usually controlled by eye of smaller refractive error so eye with larger refractive error has constant blur

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10
Q

For complete achromatopsia, what is the inheritance? 1. What vision is normal and what is absent? 2. What are the signs and symptoms? 3

A
  1. autosomal recessive
  2. rod vision normal, cone vision completely absent
  3. VA = 20/200, photophobia, no foveal reflex, and pendular nystagmus
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11
Q

For Vernier acuity compared to grating acuity, what is the loss of acuity like for anisometropes? 1. For strabismics? 2. For mixed? 3

A
  1. proportionate loss
  2. much greater loss of vernier than grating acuity
  3. intermediate more loss of vernier
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12
Q

Where does the part of V1 that normally receives signals from the fovea receive info from for an achromatic patient?

A

signals from the parafoveal retina

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13
Q

Is the loss of contrast sensitivity at high spatial frequencies higher or lower than the loss of visual resolution acuity?

A

equal

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14
Q

What develops normally in refractive amblyopia in regards to the patients vision?

A

lowest spatial frequency channels normal

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15
Q

When are patients most sensitive to refractive amblyopic damage? 1. Why? 2

A
  1. under age 5

2. culling of synapses mostly done

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16
Q

What type of vision may not be affected by a pure strabismic amblyopia?

A
  1. have normal CSF

2. good resolution acuity

17
Q

Why do the retinal cells “fire together” during development before birth?

A

wave of spontaneous activity sweeps across the retina

18
Q

Is there a relationship between the amount of blur and depth of the amblyopia?

A

yes, more blur means worse spatial frequency loss

19
Q

What happens to patients that have blurred vision in both eyes?

A
  1. critical period longer
  2. eventually, connections lost and there is VA loss in both eyes
  3. loss of motion perception
20
Q

For Vernier acuity compared to Snellen acuity, what is the loss of acuity like for anisometropes? 1. For strabismics? 2. For mixed? 3

A
  1. proportionate loss
  2. proportionate loss
  3. proportionate loss
21
Q

What is the etiology of strabismic amblyopia?

A
  1. eye turn in infancy/early childhood (more common for esotropia)
  2. may have concomitant anisometropia (reduced contrast sensitivity and grating detection acuity in affected eye)
22
Q

What will the failure to remove a cataract in a child lead to?

A
  1. unilateral amblyopia

2. severe bilateral perceptual losses

23
Q

Why do the retinal cells “fire together” during development after birth?

A

usual retinal stimulus

24
Q

What is the stereo deficiency seen in strabismic amblyopia due to?

A
  1. misalignment of the eyes (clinically and developmentally?
  2. scrambled signals from affected eye
  3. suppression of affected eye