Revision 2 Flashcards
1
Q
addition of oligomycin and DNOP
A
increases rate of respiration
2
Q
effect of glucose on respiration rate
A
no direct effect on respiration in the mitochondria
3
Q
final product of ox phos
A
water
oxygen is the penultimate product
4
Q
NADG-coenzyme reductase
A
first transporter in the transport chain
5
Q
is osteogenesis imperfecta only from de novo mutations
A
no, mutations can be inherited
6
Q
presenting symptoms of OI
A
bone fracture resp failure spinal curvature bone deformity loose joints
7
Q
what is the abnormal feature in collagen in OI
A
mutations in a1(1) chain
substitution of glycine for bulkier AA = steric hinderance
disrupts assembly of fibrils into fibres
8
Q
mutation in glycine in OI
A
G -> T
change to cysteine
make inappropriate disulphide bonds
also larger so causes steric hinderance = kinks in chain and disrupting stability
