Review Topnatch 2

Question 1

Maximal velocity of an enzyme catalyzed reaction

Answer 1

V max

Question 2

Rate independent of substrate concentration

Answer 2

Zero

Question 3

Rate proportional to substrate concentration

Answer 3

First

Question 4

Emzyme that catalyze the transfer of the amino groups of amino acids to glutamate

Answer 4

Amino transferase

Question 5

Oxidatively deaminates glutamate to liberate free ammonia

Answer 5

Glutamate dehydrogenase

Question 6

Deaminates glutamine to glutamate in the kidneys and intestines

Answer 6

Glutaminase

Question 7

Compounds in which organisms excrete excess nitrogen

Answer 7

Ammonia
Uric acid
Urea

Question 8

Amino acids which carry nitrogen fromperiphery to the liver

Answer 8

Glutamate
Glutamine
Alanine

Question 9

Function of urea cycle

Answer 9

Produces urea from free ammonia

Question 10

Location of urea cycle

Answer 10

Mitochondria and cytolpasm. Liver only

Question 11

Reactnats of ureacycle

Answer 11

Ammonia
Aspartate
Carbon dioxide

Question 12

End productof urea cycle

Answer 12

Urea

Question 13

Rate limiting step of urea

Answer 13

Carbomyl phosphate synthase 1

Question 14

3 compounds are the immediate donors of the atoms of urea

Answer 14

Free ammonia
Aspartate
CO2

Question 15

Heme synthesis location

Answer 15

Mitochondria and cytoplasm, all tissues

Question 16

Heme reactants

Answer 16

Glycine

Succynl Coa

Question 17

End product of Heme

Answer 17

e-aminolevulinic acid

Question 18

Rate limiting step of heme

Answer 18

Glycine+succynl CoA -> ALA

via ALA synthase

Question 19

Enzyme for the conversion of heme to biliverdin

Answer 19

Heme oxygenase

Question 20

Enzyme for the converion of biliverdin to bilirubin

Answer 20

Bilverdin reductase

Question 21

Amino acids degradation and synthesis

Pyruvate
Alpha-ketoglutarate
Oxaloacetate

Answer 21

Alanine
Glutamate
Aspartate

Question 22

Ketogenic amino acids

Answer 22

Lysine

Leucine

Question 23

Glucogenic amino acids

Answer 23

Valine

Question 24

Amino acid of ketogenic and glucogenic

Answer 24

Tyrosine

Question 25

Pigment derived from porphin chelates with iron, magnesium, zinc, nickel, copper or cobalt

Answer 25

Porphyrin

Question 26

Hyaluronic acid, dermatin sulfate, heparin, keratansulfate

Answer 26

GAGs

Question 27

Found in extracellular matrix of connective tissues

Answer 27

Proteoglycans

Question 28

Component of most connective tissues in the body

Answer 28

Collagen

Question 29

Found in the ground substance GAG+ protein Core

Answer 29

Proteoglycans

Question 30

Found in connective tissues which has elastic properties

Answer 30

Elastin

Question 31

Intermediate filament found in epithelial cells

Answer 31

Keratin

Question 32

Defense of the body aainst foreign bodies harmful and nonharmful

Answer 32

Immunoglobulins

Question 33

Thick filaments found in the muscles, involved in muscle contraction

Answer 33

Myosin

Question 34

Thin filaments found in skeletal muscle. | Could be fibrous or globular

Answer 34

Actin

Question 35

Protein folding disorder

Answer 35

Prion disease and alzheimers

Question 36

Gluatmate is replaced by valine at position 6 of the B-globin chain. Causing hemoglobin that polymerizes inside the RBC.

Answer 36

Sickle-cell disease

Question 37

Synhtesis of alpha chains is decreased or absent

Answer 37

Alpha thalasemia

Question 38

Spectrin deficiency causes spherical RBC that are rapidly culled by the spleen

Answer 38

Hereditary sphercytosis

Question 39

Blue sclera, multiple fractures, conductive hearing loss

Answer 39

Osteogenesis imperfecta

Question 40

Berry aneurysms, hyperextensible skin, hypermobile joints, tnedency to bleed.

Answer 40

Ehlers-pauls syndrome

Question 41

Loose teeth, sore spongy gums, poor wound healing, petechiae on skin and mucous membranes

Answer 41

Scurvy

Question 42

Hereditary nephritis with sensorineural hearing loss

Answer 42

Alport syndrome

Question 43

Aortic dilatation, dolichistenimelia, acromegaly

Answer 43

Marfan syndrome

Question 44

Panacina emphysema and liver failure

Answer 44

a-1 antitrypsin deficiency

Question 45

Hepatolenticular degeneration from accumulation of copper in tissues with low levels of ceruplasmin

Answer 45

Wilsons disease

Question 46

Musty body odor, mental retardation, fair skin, eczema

Answer 46

Phenylketonurin

Question 47

Urine turns black upon standing, associated with debilating arthralgias

Answer 47

Alkaptonuria

Question 48

Decreased pigmentation that increase the risk for skin cancer

Answer 48

Albinsim

Question 49

Atherosclerosis, lens subluxation, stroke, MI, osteoporosis, tall stature

Answer 49

Homocystinuria

Question 50

Staghorn calculi due to inherited defect of renal tubular amino acid transporter

Answer 50

Cystinuria

Question 51

Mental retardation from blocked degradation of branched amino acids

Answer 51

Maple syrup urine disease

Question 52

Photosensitivity, chronic inflammation to overt blistering and shearing in exposed areas of the skin due to defects in heme synthesis

Answer 52

Porphyrias

Question 53

Protein deprivation that is relatively greater than the reduction in total calories

Answer 53

Kwashiorkor

Question 54

Caloric deprivation is relatively greater than the reduction in protein

Answer 54

Marasmus

Question 55

Substrate concentration at which the reaction velocity is equal to 1/2 Vmax

Answer 55

Michaelis constant