Review: TB/STIs

Question 1

Treatment of Active TB + Duration

Answer 1

-Rifampin (RIF): 5-7x/wk for 8 weeks, then 5-7x for 18 weeks (continuous)

-Isoniazid (INH): 5-7x/wk for 8 weeks, then 3x for 18 weeks (continuous)

-Pyrazinamide (PZA): 3x/wk for 8 weeks

-Ethambutol (EMB): 7x/wk for 2 wks, then 2x/wk for 6 weeks
*(stop once RIF/INH sensitivity confirmed)

Question 2

TB TX AEs: RIF

Answer 2

Orange/Red fluids, hepatoxicity, SJS, TENS (LOST)
*cyp and pgp

Question 3

TB TX AEs: INH

Answer 3

BBW for hepatitis
-Peripheral neuropathy
*give with pyridoxine (B6, 25-50 mg)
-Anemia, Agran, Thrombo, optic neuritis

HAPATO

Question 4

TB TX AEs: PZA

Answer 4

Hepatoxicity, hyperuricemia
-arthralgias, myalgias, NV, malaise

CI: acute gout or sever hepatic

LUMMAN

Question 5

TB TX AEs: EMB

Answer 5

-Ophthalmic toxicity
(optic neuritis, color blindness, loss of vision)
*Eye exam before starting
-Hepatoxicity
-Confusion, hallucination, HA

CI: optic neuritis, young children, unconscious, can’t report vision changes

YOU COL

Question 6

Treatment of Latent TB

Answer 6

RIF daily x 4 months

INH + RIF x 3 months

INH + Rifapentine once weekly x 3 months

ISO x 6-9 months

Question 7

Genital Herpes

Answer 7

1st Ep: painful, systemic
-TX: Fam/Acy/Val x 7-10 days

Recurrent: mild/mod, not systemic
-TX: Fam x 1d, Acy x 5d

Suppressive
-TX: Fam/Acy/Val x 1 year

Question 8

Syphilis

Answer 8

Treponema Pallidum
-Painless ulcer

1, 2, early latent: Benthazine PCN G 2.4 x 1 dose

3, late latent: Benthazine PCN G 2.4 x 1 dose for 3 weeks

Neuro: Crystal PCN G 18-24 mu for 10-14 days

Question 9

Chlamydia

Answer 9

Chlamydia Trichomonas

Doxycycline 100 mg BID for 7 days with food

Question 10

Gonorrhea

Answer 10

Neisseria Gonorrhea

Ceftriaxone 500 mg if < 150 kg, 1000 mg if > 150 kg

Azithromycin 1 g x 1 dose if pregnant