Misc

Question 1

ANC Calc

Answer 1

= WBC x (% PMN + % Bands)

Question 2

PCT

Answer 2

< 0.1 = abx strongly discouraged

0.1-0.25 = abx discouraged

0.25-0.5 = abx encouraged

> 0.5 = abx strongly encouraged

Question 3

Ceftriaxone side chains

Answer 3

Caution with:
-Cefotaxime
-Cefepime

Cefazolin has none

Question 4

Vanco infusion max

Answer 4

1 g over 1 hour

IF answer is 1500 g then infusion should be 1.5 hours, etc.

Question 5

AG infusion

Answer 5

always over 0.5 hours

Question 6

Vanco ideal #s

Answer 6

AUC 400-600

Peak = 30

Trough = 10

Question 7

Steps for empiric calc

Answer 7

1. Calc Vd (first is for Vanco, second is for AG)
2. CrCl = Clmed = Crock = (140-age)Wt / 72Scr
   = times 0.85 if female
3. Calc K ( V/Cl ) and half life ( 0.693/K)
4. Select Model
   = 6Tinf =< half life (BOLUS)
   = 6Tinf > half life (SIM)
5. Use MD equation to find Cssmax or min
6. Use C = Co*e^-kt for other max/min

Question 8

Different Wt Calc

Answer 8

TBW = actual bw

Ideal = 45.5 (or 50) + 2.3 * every inch over 5 ft

Question 9

When to use Ts

Answer 9

BOLUS
tmax = 0
tmin = tau = Q time

SIM
tmax = 0
tmin = tau - ting (tau minus 1 or 0.5)

Question 10

KINGELLA TX

Answer 10

-Ceftriaxone
-FQ if intolerant

Culture neg
-Vancomycin + Amp/Sul (unasyn)

Question 11

How to treat APPYS

Answer 11

Non-perforated
= Ceftriaxone

Perforated
= Zosyn, Ertapenem

Question 12

Selecting Model

Answer 12

= 6Tinf =< half life (BOLUS)
= 6Tinf > half life (SIM)