Review of Normal Gross Anatomy and Histology of the Respiratory System Flashcards

1
Q

What is the definition between upper and lower airways?

A

Upper airways are extrathoracic -> go all the way to the superior part of the trachea

Lower airways are everything below. Becomes intrapulmonary airways after branching into left and right main pulmonary bronchi

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2
Q

In what way are the lungs like the liver?

A

They have a dual blood supply, with a smaller, well-oxygenated circulation and a large, poorly-oxygenated circulation

Large - pulmonary arteries (like portal vein)

Small - bronchial arteries - arising from aorta on left and internal thoracic artery on right (like hepatic artery)

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3
Q

How do you tell pulmonary artery vs bronchial artery vs pulmonary veins?

A

Pulmonary artery - about the same size as the bronchioles they travel with (adjacent to)

Bronchial artery - also travels adjacent to, but is much smaller than bronchioles and pulmonary arteries

Pulmonary veins - empty alveolar capillaries, run in the interlobular septae and subpleural connective tissue rather than near airways

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4
Q

Where do lymphatics run in the lungs?

A

Everywhere, because we really need to keep the lung dry

Includes adjacent to airways, within interlobular septa, and in the subpleural connective tissue

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5
Q

What do the hilum of the lungs contain? How do these nodes drain?

A

Largest airways and blood vessels, as well as hilar lymph nodes (which drain to subcarinal, mediastinal, and supraclavicular nodes, before finally communicating with venous circulation via thoracic duct)

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6
Q

What two structures does the left lung contain relating to the heart?

A

Both in the upper lobe

  1. Cardiac notch - lateral deflection of border
  2. Lingula
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7
Q

How many bronchopulmonary segments are there in the right and left lungs?

A

Right - 10 segments

Left - 8 segments

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8
Q

What is a primary pulmonary lobule?

A

An acinus - unit of lung supplied by one respiratory bronchiole

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9
Q

What is a secondary pulmonary lobule?

A

Larger than a primary. It is a unit of lung supplied by a single bronchiole which gives rise to 3-5 terminal bronchioles, and is surrounded by a single interlobular septum which is continuous with alveolar septae, peribronchovascular interstitium, and subpleural connective tissue

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10
Q

Where do the pleural surfaces reflect?

A

At the root of the lung (lateral mediastinum)

Otherwise they are separated by the pleural cavity

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11
Q

What are the fissures of each lung and how are they formed?

A

Right lung - horizontal (superior and middle) and oblique fissures (middle and inferior)

Left lung - Oblique (superior and inferior)

Formed as invaginations of the VISCERAL pleura

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12
Q

What are the four layers of the tracheal wall?

A
  1. Mucosa
  2. Submucosal (with glands)
  3. Cartilage / fibromuscular layer separating adjacent rings and on posterior side
  4. Adventitia - LCT / vessels
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13
Q

What populates the mucosa of the trachea and how is it different than a bronchus?

A
  1. Tall, pseudostratified columnar epithelium with goblet cells
  2. Lamina propria connective tissue with blood vessels (to warm the air)

Difference from bronchus - no muscularis mucosae, since the cartilage is so strong

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14
Q

What is the purpose of the submucosal glands in the upper airway?

A

Serous - warms / humidifies air

Mucinous - cleaning / clearing airway with mucociliary elevator

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15
Q

What bridges the posterior wall of the trachea?

A

A transverse band of smooth muscle called the trachealis muscle, as well as fibroelastic connective tissue

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16
Q

How do bronchi differ from trachea?

A
  1. Bronchi has muscularis mucosae in the mucosal layer
  2. The cartilage is made of plates rather than continuous.
  3. Epithelium transitions from pseudostratified to simple ciliated columnar
17
Q

What is the significance of the muscularis mucosa?

A

Allows bronchoconstriction of the airways

18
Q

How do bronchioles differ from bronchi?

A
  1. No cartilage
  2. No submucosal glands
  3. Thick muscularis mucosa relative to airway lumen
  4. Simple ciliated columnar becomes simple cuboidal with club (Clara) cells
19
Q

What is the definition of a respiratory bronchiole?

A

Bronchiole lined partial by bronchiolar epithelium (with club cells) and partially be alveolar outpouchings (gas exchange)

20
Q

Where is the interstitium of the alveoli present?

A

Not always present, but if it is, it will be connective tissue between basement membrane of Type 1/2 pneumocyte and capillary endothelium

21
Q

How are adjacent alveoli connected?

A

Pores of Kohn - perforate the alveolar septae