review from ANS Flashcards
Where are M1 located
Location: CNS neurons, sympathetic postganglionic neurons, some presynaptic sites
*sweat glands: causes sweating
What is the result of ligand binding at M1 receptors
Gq/11: IP3 and DAG increase Ca
Where are M2 located
heart, SM, some presynaptic sites
*Heart: decrease HR and conduction
What is the result of ligand binding at M2
Gi inhibits adenylyl cyclase; open K channels
What are M3 located
Exocrine glands, SM, endothelium (pretty much do all the PNS effects besides sweating (M1) and decrease HR/conduction (M3))
*lungs: bronchoconstriction
Increase salivary and lacrimal secretion, miosis
What is the result of ligand binding at M3
Gq/11: IP3 and DAG increase Ca
Where are Nn located
postgang neurons, some presynaptic cholinergic terminals
What is the result of ligand binding at Nn
opening of Na, K channels, depolarization
Where are Nm located
Skeletal muscle neuromuscular endplates
What is the result of ligand binding at Nm
opening of Na, K channels, depolarization
Where are a1 receptors located
Postsynaptic effect cells esp SM (excitatory)
What is the result of ligand binding at a1
Gq/11: PLC, IP3, DAG increase Ca
What is the general effect of a receptor stimulation
increase salivation, mydriasis, nasal vasoconstriction,
Where are alpha 2 receptors located
Presynaptive nerve terminals, some SM
what is the result of ligand binding at a2
Gi inhibit adenylyl cyclase
Where are B1 receptors located
B1: postsynaptic effector cells, heart, lipocytes, brain, presynaptic adrenergic and cholingeric nerve terminals
*increase HR and force
What is the result of ligand binding at Beta receptors
all Gs stimulate adenylyl cyclase, increase cAMP
Where are B2 receptors located
postsynaptic effect cells esp SM and heart muscle
*bronchioles, heart, SM in skeletal BV
Where are B3 receptors located
postsyn effector cell especially lipocytes
*lipolysis
where are D1, D5 receptors located. What effect does ligand binding have?
brain and vascular bed
*usually Gs, stim adenylyl cyclase, increase cAMP
Where are D2-4 receptros located and what effect does ligand binding have?
Brain, other tissues
*usually Gi, inhibit adenylyl cyclase, decrease cAMP