review from ANS

Question 1

Where are M1 located

Answer 1

Location: CNS neurons, sympathetic postganglionic neurons, some presynaptic sites

*sweat glands: causes sweating

Question 2

What is the result of ligand binding at M1 receptors

Answer 2

Gq/11: IP3 and DAG increase Ca

Question 3

Where are M2 located

Answer 3

heart, SM, some presynaptic sites

*Heart: decrease HR and conduction

Question 4

What is the result of ligand binding at M2

Answer 4

Gi inhibits adenylyl cyclase; open K channels

Question 5

What are M3 located

Answer 5

Exocrine glands, SM, endothelium (pretty much do all the PNS effects besides sweating (M1) and decrease HR/conduction (M3))

*lungs: bronchoconstriction
Increase salivary and lacrimal secretion, miosis

Question 6

What is the result of ligand binding at M3

Answer 6

Gq/11: IP3 and DAG increase Ca

Question 7

Where are Nn located

Answer 7

postgang neurons, some presynaptic cholinergic terminals

Question 8

What is the result of ligand binding at Nn

Answer 8

opening of Na, K channels, depolarization

Question 9

Where are Nm located

Answer 9

Skeletal muscle neuromuscular endplates

Question 10

What is the result of ligand binding at Nm

Answer 10

opening of Na, K channels, depolarization

Question 11

Where are a1 receptors located

Answer 11

Postsynaptic effect cells esp SM (excitatory)

Question 12

What is the result of ligand binding at a1

Answer 12

Gq/11: PLC, IP3, DAG increase Ca

Question 13

What is the general effect of a receptor stimulation

Answer 13

increase salivation, mydriasis, nasal vasoconstriction,

Question 14

Where are alpha 2 receptors located

Answer 14

Presynaptive nerve terminals, some SM

Question 15

what is the result of ligand binding at a2

Answer 15

Gi inhibit adenylyl cyclase

Question 16

Where are B1 receptors located

Answer 16

B1: postsynaptic effector cells, heart, lipocytes, brain, presynaptic adrenergic and cholingeric nerve terminals

*increase HR and force

Question 17

What is the result of ligand binding at Beta receptors

Answer 17

all Gs stimulate adenylyl cyclase, increase cAMP

Question 18

Where are B2 receptors located

Answer 18

postsynaptic effect cells esp SM and heart muscle

*bronchioles, heart, SM in skeletal BV

Question 19

Where are B3 receptors located

Answer 19

postsyn effector cell especially lipocytes

*lipolysis

Question 20

where are D1, D5 receptors located. What effect does ligand binding have?

Answer 20

brain and vascular bed

*usually Gs, stim adenylyl cyclase, increase cAMP

Question 21

Where are D2-4 receptros located and what effect does ligand binding have?

Answer 21

Brain, other tissues

*usually Gi, inhibit adenylyl cyclase, decrease cAMP