Review Course Content Flashcards
Fever in returning traveler is ____ until proven otherwise?
Malaria - falciparum malaria can kill you in 24-48 hours!!
Pre-travel history?
When, where, how long are you going and why are you going there? ie. food tourism = high risk for cholera, GI illness, typhoid fever, parasites SE Asia (Bankok, Thailand for business meetings) - lower risk profile. PHx, PMHx, Family Hx
Management of traveler with fever?
More than meds!
Twinrix and ciprofloxacin
When is typhoid vaccine indicated in Canadian guidelines?
Southeast Asia & surrounding region
Biggest risk type of travel for fever in traveler?
Visiting relatives!
Antimalarials and comparison as per PHAC 2014?
- Atovaquone - proguanil - daily x 7 days post exposure. Daily dosing and $$$$
- Doxycycline - cheap, daily, photosensitivity rash and need it 30 days post exposure
- Mefloquine - once weekly dosing, frequent side effects including wild dreams!! And psychiatric sx. THUS not first line anymore!
- Primoquine - need blood test before medication taken -G6PD deficiency test. ONLY 7 days after exposure.
- Chloroquine - cheap and long term safety data
* **WIDESPREAD RESISTANCE (Check before prescribing) also has skin and corneal side effects.
Non-pharmacological management and recommendations for pre-travel counseling
- PREVENT - Limit high risk activity - night driving (don’t do it), sex tourism (use PREP or condoms)
- QUIT - smoking, don’t check meds in luggage!!, risky activity
- REFER -travel clinic
- Travelers diarrhea
BIGGEST M&M In patients who are travelers?
MVA’s!!!!
How to prep for travelers diarrhea?
- Pack: Oral rehydration solution, loperamide*, azithromycin, bismuth subsalicylate** (can take QID for prevention)
- Take loperamide for mild diarrhea if no dysentry or blood.
- *Pepto bismol - can take QID for prevention
2. Boil it, peel it, cook it, or forget it
3. Ice cubes, salads, uncooked veg
4. Use bottled water
5. Wash and sanitize hands often
How to manage altitude sickness?
Acetazolamide 125 mg BID Dexamethasone 4 mg BID** Nifedipine Sildenafil/Tadalafil Prophylactic salmeterol
**Also treats high altitude cerebral edema AND get em off the mountain!
NOT recommended: ginko biloba
Aspirin a day?
Primary prevention for CV disease? DON’T START IT!
If already taking? Evidence to discontinue less clear. Do risk assessment
Studies: ASPREE, ARRIVE, ASCEND, ACCEPT-D
HCV Screening? Who are the higher risk patients?
NOPE.
Unless higher risk:
Hx incarceration, blood products/organ transplant before 1992, recent immigrants, IVDU
AAA Screening?
Men 65-80 yo - one time abdo ultrasound
Women - NOPE
CFPC Preventive Health Checklist?
Learn it. CFP 2020. Get it off bit.ly/vitalfm-checklist
CFPC Preventive Health Checklist?
Learn it. CFP 2020. Get it off bit.ly/vitalfm-checklist
FALL in PM? How can we prevent the hip fractures?
Best question: How many falls in the last one year?
FALL: review active health status, screen for FALLS yearly
P: Review pain control
M: Medications?
Immigrants and Refugees Guidelines?
Check out Ottawa guidelines from CMAJ 2011 or CPS have good one: caringforkids.ca new to Canada
Immigrants & Refugee Canadian Practice Recommendations?
- Infectious Disease - OFFER testing and vaccines, INTERPRETER, Consider RISK LEVEL for country (ex. HIV, TB, HCV
- Chronic Disease
- Mental Health
- Women’s Health
Recommends for Interpreter?
- Not a family member
- Don’t pull someone from waiting room
- LOTS of access for interpreters!
- Don’t use google translate as not standard of care
How do we test for TB?
Intradermal (IGRA)-interferon gamma release assay
>95% Specificity for latent TB only
-Don’t use to dx ACTIVE TB
4 meds to tx TB?
Rifampin
Isoniazid
P
E
4 meds to tx TB?
Rifampin
Isoniazid
Pyrazinamide
Ethambutol
Painless hematuria is
CANCER until proven otherwise
ALSO a sx. of schistosomias and consider this for
If fever and travel test for malaria. If asymptomatic?
asyx: DON’T Test
Test via: Thick & thin smear
Test for malaria antigen
If patient has no vaccine record and is immigrant?
GIVE THESE!!! (50% don’t have them on avg.)
TDAP-IPV
MMR
TEST first:
HBV
Varicella (if over 13 years old)
Immigrants Screening?
Dentist
Diabetes (use HgbA1C)
Vision - optometrist
Lead poisoning
What mental health like conditions should you NOT screen for in immigrants? What should you screen for?
Don’t screen for maltreatment of children, domestic violence or PTSD unless presenting complaints.
- Are you down, depressed or hopeless? Little interest in doing things? (anhedonia)
- This is the PHQ-2 and first 2 questions of PHQ-9.
Women’s Health in immigrants?
OFFER screening: serum iron or ferritin
women and Children FERST
TRAVEL HISTORY?
Years later…patient has a cough?
Vague GI sx?
TB risk region?
Test for strongyloides if walking barefoot!
TRAVEL HISTORY?
Years later…patient has a cough?
Vague GI sx?
TB risk region?
Test for strongyloides if walking barefoot!
SCZ Guidelines - Initial Workup?
Full history
FUNCTION (sexual function - pregnant????)
SCZ Guidelines Top 5 Recs?
1st episode: antipsychotic How long? 18 months 1st vs. 2nd gen are equal Oral = Depot (patient preference) -NNT = 7 to avoid patient admission Treat Comorbid depression
NMS symptoms and treatment?
FARM: Fever Autonomic dysregulation Rigidity Mental status changes
-Even low dose, any stage of treatment, can be if escalating doses or dose changes.
Tx: Stop medication IVNS Ice packs Dantrolene Bromocriptine
Management of SCZ?
Meds Safety first!! -SI and HI Family counseling Vocational rehab Finances? Day hospital? Admission? Detox? Adherence? Pregnant? SUD?
Adult non resolving pneumonia?
Is it the wrong bug, drug, or diagnosis!?
Typical?
Atypical?
Mycobacterium? Pneumocystis?
Non- abx treatment for abscess, sepsis, appendicitis, laceration and nec fasc?
Abscess - drain it, and de-capsulate
Sepsis - supportive (fluids, pressors, blood cx)
Appendicitis - conservative therapy treatment emerging
Laceration - TETANUS BRO
Nec Fasc - EMERGENTLY DEBRIDE!
Abx Trends?
ORAL after IV? May be non-inferior to prolonged IV
Pneumonia Guidelines (2019)
DON'T -use term healthcare associated PNA term -DON't use CURB-65 score. -procalcitocin -order sputum C&S or blood culture unless patient is sick! Sick = severe CAP as per PSI score. -prescribe steroids -XRAY not required
DO:
- use PSI score
- Test for influenza (at risk for MRSA PNA)
- Treat with antiviral if influenza positive AND abx if PNA expected
Non-resolving PNA: 37 M non smoker, low grade fever, SOBOE and occasional cough. Pulse 102 / 22/ 106/68, afebrile
Generalized lymphadenopathy
Prev got mixofloxacin and hasn’t improved
WBS of 3.6 and low lymphocytes
CXR is normal.
TROC history
Vitals
Treating the wrong bug? drug? or diagnosis?
Repeat CXR: Diffuse interstitial infiltrates, CD4 110, bronchoscopy was PJP!
Weird and Wonderful ddx of PNA?
PJP - pneumocystis Jirovecii pneumonia Mycobacterium Avium Complex (MAC) TB Influenza Toxoplasmosis
CXR normal! Clinical picture unclear?
Get SERIAL dude!!!
Serial exams, serial ECG’s, Serial Imaging
*Also relevant for chest pain etc. Imaging evolves over time!
What 3 infectious diagnoses should you think about testing together?
HIV-TB-HCV
4 factors affect antibiotic choice in pneumonia (and one bonus)?
- Allergies
- Drug drug Interactions (ex. warfarin)
- COPD co-treatment needed?
- Are we covering for aspiration PNA? (anaerobes!)
- Outbreak!? (Think legionaires, COVID-19)
When do you use antibiotics in COPD?
In exacerbations!
COVID-19 CXR imaging?
Interstitial PNA
Most common cause for PNA in ALL people?
Strep Pneumoniae!!!!
In kids…uncomplicated PNA recommendations?
Amoxicillin - banana flavoured!! is still first-line
Routine X-ray post treatment is NOT recommended unless clinically indicated.
Hypertension screening best practice?
Automated> manual
Gold standard 24 h ambulatory
If chubby or muscly arm? Use wrist device (sit at level of heart)
-Take BP when patient relaxed, no coffee, no smoking, feet flat, no gum
Out of office measurements of BP recommendations?
- CRITICAL!!
- White coat HTN effect is real!
- BP cuffs aren’t that expensive anymore
Diagnosis of HTN?
Automated office BP mean >135/85
Office BP >140/90
Diabetes >130/80 if 3 office measurements on different days
If any above: get outpatient BP
Amb >135/85
Diabetic 130/80
Workup for HTN?
Do a lipid panel
Non fasting OK
Also K, Na, Creatinine, urinalysis, HbA1c, diabetic patients (urinary albumin), ECG
-MAKE SURE NOT PREGO!!
% of cases are essential HTN?
90%
Secondary HTN?
Atherosclerosis Big belly, bruits, bad kidneys Catecholamines (pheo) Drug, diet Endocrine sleep apnea and stress
CPAP does NOT?
Decrease cardiovascular events
or decrease mortality
First line for eHTN?
- Diet
2. Lifestyle
When do you start treatment for eHTN?
Based on RF’s:
Low
High
Diabetes
All others
HCTZ and skin cancer?
- uncertain and not proven
- Possible 4x incr risk after 3 years of:
- Non melanoma skin CA
- Inform patients and
-consider switch if higher risk:
light skin
personal or fam hx
Immunosuppressed
HTN ABC’s to avoid!?
AVOID:
Alpha blocker alone
Beta blocker if older than 60 yo
ACE or chlorthalidone if black
Chlorthalidone in HTN?
Incr risk diabetes, renal, e’lyte abnormalities VS HCTZ (similar CV benefit for both)
Prefer LONG acting diuretics (chlorthalidone or indapamide)
What does taking antiHTN at bedtime do?
Reduce CV disease risk by nearly half (hazard ratio is ~0.55?)
HTN urgency vs. Emergency?
Urgent: Rapid treatment is NOT successful or necessary
Emergency: Asymptomatic DBP >130
Acute heart, brain, aorta or kidney damage
Pre-eclampsia or PHEO
Treat with: Nifedipine Labetolol Captopril Clonidine Nitrates
Resistant HTN definition? #1 reason?
if on 3 meds REFER! This = resistant
4th agent: Spironolactone has BEST effect to lower BP (monitor kidney fcn)
Reason: NOT TAKING THE MEDICATION!
Other: not appropriately prescribed?
Lifestyle: salt, tobacco, sedentary, obesity, alcohol
Other meds: naproxen, NSAID’s, contraception, steroids, licorice, OTC medications
HTN in kids?
> 3yo then measure
Check in RIGHT arm because if coarctation of aorta then falsely low BP in LEFT arm
Workup = ECHO and CVD risk assessment
HTN in pregnancy?
AVOID/CONTRAINDICATED: ACE and ARB pre-conception and in pregnancy
BREASTFEEDING: Choose labetalol, methyldopa, nifedipine
COUNSELING PRE-CONCEPTION: Look at BMI!
Lifestyle treatments of HTN?
Sodium <2000 mg/day (drop 5mmHg)
Weight decrease 4.5 kg (drop 7 mmHg)
Alcohol -decrease by 2.7 drinks/day (drop 4 mmHg)
Exercise Rx - 30-45 mins 3x/week (10 mmHg)
Diet - DASH (10 mmHg)
Relaxation - CBT (10 mmHg)
When do you start treatment for HTN?
START treatment if? Low risk: >160/100 (goal: <140/90) High risk: >130 (<120 sys) Diabetes: >130/80 (<130/80) All others: >140/90 (<140/90)
Febrile neutropenia?
- Recognize early!!!
- Stabilize (fluids and ABX)
- Avoid rectal temp, look in mouth (mucositis), look for source (consider fungal)
Fever without cause -when to do tissue biopsy? What other tests?
Full workup previously normal….
Tissue biopsy? Liver Node Temporal artery Bone marrow
SPEP Vasculitis/autoimmune ECHO HIV, TB test Dental assessment Viral cultures
No idea wtf going on with this weird AF PNA?
Serial exams
Serial ECG’s
Serial imaging
Serotonin Syndrome
- GI symptoms and NMS does not
- myoclonus
Kid prevents with 5 days of fever and he is 5yo?
KAWASAKI’s
CRASH
Conjunctivitis Rash Adenopathy Strawberry tongue Hands and feet
Bad bad bad -CAA: Coronary artery aneurysm
ASA and IVIG in KAWASAKI
Don’t forget about MIS-C!!
-Children 0-19 with fever >3 days and COVID 19 positive or close contact, and unexplained ESR/CRP elevation
Kid presents with 5 days of fever and he is 5yo?
KAWASAKI’s
CRASH
Conjunctivitis Rash Adenopathy Strawberry tongue Hands and feet
Bad bad bad -CAA: Coronary artery aneurysm
ASA and IVIG in KAWASAKI
Don’t forget about MIS-C!!
-Children 0-19 with fever >3 days and COVID 19 positive or close contact, and unexplained ESR/CRP elevation
Issues with Framingham?
OVER ESTIMATES RISK
Screen who for hyper
Men >40yo
Women >50 (or post menopauisal)
EARLIER:
Smoker
Screen who for hyperlipidemia? (incomplete)
Men >40yo
Women >50 (or post menopauisal)
EARLIER:
Smoker
DO NOT in hyperlipidemia
Treat LDL target (CCS disagrees rx. to <2 or 50% reduction or <1.8 if ACS) Use framingham in renal dz make patients fast Order Apo-B, CRP Use ezetimibe for primary prevention
DO NOTs in hyperlipidemia
DO NOT in HYPERLIPIDEMIA: Treat LDL target (CCS disagrees rx. to <2 or 50% reduction reduction or <1.8 if ACS) Use framingham in renal dz make patients fast Order Apo-B, CRP Use ezetimibe for primary prevention
CAM for high lipids?
O3FA FIRST LINE FOR HYPERTRIGLYCERIDEMIA
25% risk reductions
Effective and safe except poor GI sx
CAM for high lipids?
O3FA FIRST LINE FOR HYPERTRIGLYCERIDEMIA
25% risk reductions
Effective and safe except poor GI sx
Dumb Mnemonic for Dizziness that is validated?
TiTrATE (validated tool):
Timing
a. How long does it last? seconds, minutes, days. When feel dizziness how long does it last? Does it go away?
Triggers
A thorough exam
Don’t need to ask med school questions for lightheaded or room spinning? Get a double yes that is UNHELPFUL
Dizziness timeline clues?
In shower, look up, and dizzy but resolves in 30 seconds?
20-30 mins long ladsting?
Constant/days?
BPPV
Orthostatic Hypotension
Meniere’s last longer
Migraine, neuritis, stroke
Triggers of dizziness?
Medication start or change
Trauma (barotrauma)
BPPV or orthostatic hypotension
Associated symptoms of dizziness?
Migraine aura - think migraine
Blood, Blisters, Back of neck pain -Ramsay hunt, trauma, vertebral artery dissection
Chest pain - aortic dissection
Deafness (1 side) -Meniere’s (tinnitus, fullness, dizziness)
Vertigo exam includes?
Orthostatic BP
GAIT (stroke?)
HINTS + loss of hearing exam - head impulse, nystagmus, test of skew
Dix-Hallpike
Where to REFER for dizziness?
ENT Neurology Vestibular rehab Physiotherapy OT Psychiatric comorbidity with vertigo: 37-50%
Tdap in pregnancy?
EVERY pregnancy at 28-32 weeks to prevent pertussis in the lil infant even if the mom got it recently.
YEARS criteria?
Look it up RIGHT NOW!
PNA and steroids?
NO (IDSA guidelines)
Red or black stool ddx?
IF not blood:
beets
iron
bismuth subsalicylate
Deprescribe PPI?
Stop or taper slowly
Step down (H2 antagonist)
Reduce: on demand, EOD
Ddx of Lower GI bleed?
ROYAL Family: Kate is always pregnant = Hemorrhoids (statistically) Queen Elisabeth (old AF) = Probably your aspirin (RULE OUT BAD THINGS)
Treatment for EVERY Acute Situation?
ABC MOVIES
Airway
Breathing
Circulation
Monitor Oxygen Vitals IV ECG Sugar check
SERIAL ABC’s, VITALS, ECGs
Acute GI bleed myths and facts?
Increase hemoglobin? Transfuse ONLY if fluids not working and Hb <70
Decrease stomach contents? Decrease acid! PPI bolus (non variceal), Decrease blood/clots? Erythromycin
Scope Urgently? Scope by 6 hours does NOT reduce mortality compared to 24 hours.
Ceftriaxone? IF cirrhosis or varices? Ceftriaxone and somatostatin
NO varices? NO other drugs - don’t give transexamic acid as NO benefit and doubles risk of VTE
Prevent GI bleed?
PPI and H2RA
Anxiety RFs? Don’t miss!?!?
Family history PHx of mood or anxiety ACEs Female Chronic medical illness Behavioural inhibition
Don’t MISS: SUICIDE Assessment!
-Anxiety is INDEPENDENT RF for suicide completion (controlling for mood disorders)
PTSD treatment?
VPS + F: Venlafaxine Paroxetine Sertraline Fluoxetine
CBT (trauma focused)
Group Therapy
Debrief all trauma victims?
NO WAY!
OCD
- Obsessions and/OR compulsions
- time consuming or distressing
- Significant impairment in social or occupational functioning
OCD: O’s are ego dystonic
OCD treatment?
SSRI’s except citalopram
First line augmentation: aripiprazole, risperidone
Exposure response prevention (ERP) (Gold standard type of CBT)
Generalized anxiety disorder meds? Most effective for GAD?
VPS PEAD: Venlafaxine Paroxetine Sertraline Pregabalin Escitalopram Agomelatine Duloxetine
MOST effective: Pregabalin, duloxetine, venlafaxine, escitalopram,
Also (but smaller): Mirtazapine, sertraline, buspirone, agomelatine AND quetiapine, paroxetine and BZD’s.
A word on BZD’s for anxiety…
- NOT monotherapy
- Avoid if on opioids
- Consider risk and discuss dependence
- Avoid high doses or large quantities
- Avoid in elderly!! Increases all cause mortality.
Social anxiety treatment?
VPS PEF: Venlafaxine, paroxetine, sertraline, pregabalin, escitalopram, fluvoxamine
New SADPERSONS?
Precipitating factors: Drugs/alcohol (50% of SA's involve EtOH) Access to means Life events New terminal/chronic dz diagnosis Media effects
Predisposing factors: Neuropsychiatric disorders Family history Previous attempts ACEs Socioeconomic status
CFI-S?
Convergent functional assessment for suicide
- good to excellent predictive value
- 22 questions
Antidepressant efficacy?
AD’s effective by 6 weeks?
-Up to 1/3 will not show early response by 6 weeks
DSM-5 Mimics of depression
Hormones Grief Drugs Bipolar Tumor Delirium
Bipolar disorder or MDD?
<25 yo
>5 episodes
-Quick on/off of episodes
-Atypical features (hyperphagia, hypersomnia, leaden paralysis, longstanding interpersonal rejection sensitivity)
-depression with psychotic features
-quick response, but wear off of efficacy.
WOW FRAMEWORK for delivering bad news?
Wish we didn’t have to discuss this hard topic?
Worry convo will be difficult?
Wonder if?
GOALS are VITAL
Recognize Strengths (trauma and violence informed discussion)
Recognize abilites
Family
Teach when breaking difficult news?
Advanced directives (CPR, feeding tubes, intubation)
Estate planning?
Will?
Teach how to break news to family - offer to help
When can you terminate a patient-physician relationship?
Check with regulatory body!
Cluster A PD’s? B? C?
A:
Schizoid - Evyn Peters (no emotions, enjoys nothing, likes to be alone)
Schizotypal - Willy Wonka
Paranoid - suspicious AF
B:
Borderline - fear abandonment, self harm, identity issues
Narcissistic - entitled, no empathy, think they’re special
Histrionic - Anjena
ASPD - No remorse, lies, steals,
C:
Dependent - can’t make any decisions ever
Avoidant - extreme version of social anxiety
OCPD - all med students ever. Neurotic, controlling, morally scrupulous, perfectionistic
URTI’s and honey?
Honey works the BEST for kids with URTI’s!
Side effects of lithium
Nausea, vomiting, confusion, concentration, hypothyroid, tremor, diarrhea, ataxia, ECG changes (inverted T waves), weight gain
Labwork for lithium
Lithium level, creatinine, TSH, beta-HCG, calcium
Therapeutic window for lithium
0.6-1.2
3 Methods other than injected anethetic
Topical anesthetic, distraction, sedation
How to reduce pain of injection
Smallest needle possible, warm anesthetic, bicarb, injecting slowly
Alternatives to lidocaine
Tetracaine, procaine, preservative free lidocaine
Complications from toe surgery
Cellulitis, ischemia, nec fasc, reperfusion injury, allergic reaction
Key features of infection
Proximal migration of the lesion, leukocytosis, bony involvement on x-ray, CRP, Pain with passive stretch, fever
Treatment for pediatric asymptomatic bacteriuria
Nothing
When do you treat asymptomatic bacteriuria? List 2
Renal transplant, invasive urologic procedures
What drugs are most likely to cause serotonin syndrome? List 3
SSRI, SNRI, MaOIs
Also triptans, stimulants.
What is on your differential for altered mental status? List 7
Drugs - anti-cholinergic toxicity, malignant hyperthermia, NMS, EtOH/benzo withdrawal Infection - meningitis, encephalitis Metabolic - thyroid storm Failure (liver/kidney) Anemia Cerebral infarct/bleed Endocrine Structural/space occupy
What are the signs and symptoms of serotonin syndrome? List 6
Mental status changes (agitation, delirium) Autonomic dysfunction (changes in vitals) Neuromuscular dysfunction
What is one different symptom in Neuroleptic Malignant Syndrome and not in Serotonin syndrome?
NMS = Rigidity
Serotonin syndrome = Gi symptoms and hypereflexia/clonus
What is the treatment for a Toddles Fracture (Childhood Accidental Spiral Tibial fracture (CAST))?
Non-surgical. Backslab or boot.
What are 5 diagnoses for pediatric limp?
Leg-calves-Perthes
Infection/Inflammation
Malginancy (Ewing’s sarcoma/osteoscarcoma
Pain (fracture)
Slipped capital femoral epiphysis (Half black/half hispanic obese boy)
Something else (referred from above or below)
What is the most common organism for pediatric osteomyelitis?
S. aureus
What are the cutoff values for postural hypotension
20 systolic, 10 diastolic within 3 minutes of standing.
List 8 causes of orthostatic hypotension with compensatory tachycardia.
Dehydration (diarrhea/adrenal insufficiency, dialysis, diuretics, digoxin, antibiotics, cholinesterase inhibitors.
Dysfunctional Heart (myocardium, aortic stenosis)
Drugs (anti-hypertensives, anti-anginas, anti-parkinsonians, anti-depressants, anti-psychotics, anti-BPH meds)
Deconditioning
List 2 causes of orthostatic hypotension without compensatory tachycardia.
Low B12, hypothyroidism, EtOH abuse, diabetic neuropathy, parkinsonism, amyloidosis, beta blocker.
What are 6 possible treatment options for plantar fasciitis?
Weight loss, NSAIDs, stretching, glucorticoid injection, night splinting, orthotics, hypotension.
What is on your differential for anal mass?
Colorectal cancer, Rectal porolapse/varices Anal wart Polyp Skin tag`
What conservative measures are used to treat hemorrhoids?
List 4
PEG Weight loss Increase fibre intake Increase fluid intake Increase physical activity Stool softener Cold packs Sitz baths Baby wipes NSAIDs
When can you start sleep training?
6 months.
How do you teach sleep training?
Bedtime routine.
Put baby to bed when tired
If crying allow for 2-5 minutes then reassure if needed. Then return and increase intervals between consoling
Maternal benefits to sleep training.
Better quality maternal sleep
Better maternal mood
Better maternal energy
Differential for fever and diarrhea. List 8
Malaria Dengue fever Rickettsial disease (Typhus) Waterborne (Typhoid) Urinary infection Respiratory infection Skin infection Traveler's diarrhea
What tests to do for stool parasites?
Stool O&P
Rectal biopsy
Urine examination for parasite eggs
What drugs treats trematode flatworms?
Praziquantel